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4.
Explain the role of toxicological parameters LOAEL in ensuring the safety of a drug candidate. explain at your own words?
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- Explain the role of toxicological parameters TD50 in ensuring the safety of a drug candidate. explain at your own wordsExplain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate. Briefly explain this at your own wordsWhat are the different toxicological parameters in ensuring the safety of a drug candidate? explain at your own words
- Explain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate.Explain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate. Explain this at your own wordsExplain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate. explain this in 600-1000 words,please explain at your own words
- 7. What are the determinants for drug liposolubility?1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…4.Why is it important to include control groups and placebos in studies of the ergogenic properties of any substance or phenomenon?
- 1. Explain the importance of solubility in drug product formulation. 2.1. Create drug study of PROPRANOLOL that includes the GENERIC NAME, CLASSIFICATION, PHARMACODYNAMICS, INDICATIONS AND 10 NURSING CONSIDERATIONS. 2. Create drug study of PARACETAMOL that includes the GENERIC NAME, CLASSIFICATION, PHARMACODYNAMICS, INDICATIONS AND 10 NURSING CONSIDERATIONS. Thank you! :)1. What is the drug target?