Why is the binding of oxygen to hemoglobin cooperative while the binding of oxygento myoglobin is not?A) Myoglobin has more x-helix than hemoglobinB) Hemoglobin has more iron (Fe) atomsC) Hemoglobin has more than one subunitD) Myoglobin is affected by changes in pH

Hemoglobin is a protein found in red blood cells that transports oxygen to organs and tissues and…

Answered: Why is the binding of oxygen to…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Which process is most responsible for the sickling of cells seen in sickle cell disease? A) aggregation of the oxygenated R form of hemoglobin-S to form insoluble fibers b) aggregation of the deoxygenated T form of hemoglobin-S to form insoluble fibers c) Hemoglobin-S does not contain heme d) Hemoglobin-S contains a mutant form of heme which will not bind oxygen A person with sickle-cell trait is very unlikely to catch which disease? A) malaria b) colon cancer c) avian flu d) whooping cough
Carbon monoxide (CO) is toxic to humans because it: A) is rapidly converted to toxic CO2. B) binds to the globin portion of hemoglobin and prevents the binding of O2. C) binds to myoglobin and causes it to denature. D) binds to the heme portion of hemoglobin and causes heme to unbind from hemoglobin. E) binds to the Fe in hemoglobin and prevents the binding of O2.
The iron (Fe), ion in the heme group of hemoglobin is bound to a: OA) Cystine OB) Histidine C) Proline OD) Glutamic acid E) Valine
The sigmoidal, cooperative binding curve commonly observed for hemoglobin is a result of: a) competition between CO2 and O2 for heme binding. B) competition between heme and distal His for O2 binding c) competition between BPG and CO2 for binding at the central cavity site d) T to R transition Hemoglobin has a tendency to release its oxygen to the tissues because: a) in this region pH is high and O2 concentrations are low b) in this region both pH and O2 concentrations are low c) in this region both pH and O2 concentrations are high d) there is much BPG in this region Which statement about fetal hemoglobin is not true? A) fetal hemoglobin has gamma chains instead of beta chains b) fetal hemoglobin binds BPG less strongly than maternal hemoglobin c) fetal hemoglobin binds oxygen less strongly than maternal hemoglobin d) fetal hemoglobin binds oxygen more strongly than maternal hemoglobin Which process is most responsible for the sickling of cells seen in sickle…
Why does Fe2+ not fit perfectly into the center hemoglobin's heme pocket, while Fe3+ does ift perfectly into center hemoglobin's heme pocket? A) Fe2+ has a larger effective nuclear charge than Fe3+ . B) Fe2+ is to reactive to stably fit into hemoglobin's heme pocket. C) Fe2+ had a wrinkled shirt D) Fe2+ is repelled by the heme's coordinating nitrogens E) Fe3+ is denser and has a smaller ionic radius than Fe2+
Most of the oxygen transported in blood is A) Attached to the plasma membrane of red blood cells B) Bound to the globin portion of hemoglobin C) Bound to the heme portion of hemoglobin D) Dissolved in the cytoplasm of red blood cells
1. a) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would decrease Hemoglobin’s O2 binding affinity. b) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would eliminate Hemoglobin’s positive cooperativity.
Which of the following can affect the binding of oxygen to hemoglobin? A) The pH of plasma OB) The levels of 2,3-bisphosphoglycerate C) Albumin levels in plasma D) a and b E) a and c OF) a, b and c
#3 The heme group is a prosthetic group in: 80 F3 וח E D A) Fetal hemoglobin B) Adult hemoglobin C C) Myoglobin D) a and b E) a, b, and c F) b and c $ 4 F4 R F % 5 V ܀ F5 T G ^ B MacBook Air F6 Y H & ◄◄ F7 U N * 00 8 J DII F8 - M ( 9 K DD F9 O V I :) 0 4 F10 P |
Oxygen and hemoglobin bind in a reversible manner to form______a) Carboxyhemoglobinb) Oxyhemoglobinc) Methoglobind) BPG
Which one of the following statements concerning Hb (hemoglobin) A1c is CORRECT? Question 4 options: a) HbA1c contains glucose molecules b) The concentration of HbA1c in the red blood cells (RBCs) decreases as RBCs age in the circulation c) Insulin injection can decrease the amount of HbA1c in the blood d) Weight is correlated with HbA1c concentration
1)The form of hemoglobin with heme bonded to carbon monoxide is________a) oxyhemoglobin.b) deoxyhemoglobin.c) methemoglobin.d) carboxyhemoglobin.e) nitro hemoglobin. 2) Surfactant in the lungs prevents_______a) compliance.b) elasticity.c) surface tension.d) gas exchangee) increased blood flow. 3) Hypoventilation can correct______a) metabolic acidosis.b) respiratory acidosis.c) metabolic alkalosis.d) respiratory alkalosis.e) all of the above 4) In restrictive pulmonary disease, ______ is decreased. a) tidal volumeb) total lung capacityc) functional residual capacityd) expiratory volumee) residual volume 5) Which of the following substances is NOT excreted in the urine of healthy people?a) Penicillinb) K+c) glucosed) bicarbonatee) Nat

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Why is the binding of oxygen to hemoglobin cooperative while the binding of oxygen to myoglobin is not? OA) Myoglobin has more x-helix than hemoglobin B) Hemoglobin has more iron (Fe) atoms C) Hemoglobin has more than one subunit OD) Myoglobin is not affected by changes in pH