Which of the following statements about cancer is correct? A. Cancer stem cells can make tumors resistant to chemotherapy. B. Intra-tumoral heterogeneity makes it easier to treat cancer. C. Mutation in p53 is a type of passenger mutation. D. One driver mutation is more than sufficient for the production of a cancer phenotype.

Which of the following statements about cancer is correct? A. Cancer stem cells can make tumors resistant to chemotherapy. B. Intra-tumoral heterogeneity makes it easier to treat cancer. C. Mutation in p53 is a type of passenger mutation. D. One driver mutation is more than sufficient for the production of a cancer phenotype.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section12.10: Genomics, Epigenetics,and Cancer

Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...

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With regard to cancer cells, which of the following are true? A. Cancer cells are clonal, meaning that they are derived from many different cells that all underwent the same clonal mutation. Cells usually accumulate many mutations over time, and this results in cancerous growth. B. Almost all cancers are caused by oncogenic viruses. no Benign tumors are dangerous because they can easily invade surrounding tissue and spread to other locations in the body. DE. Cancer cells are unable to control their division.
Which of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
Which of the following statements are true about the rate of mutation in tumor cells (select all that apply)? A. Mutation rate of tumor cells is reduced compared to normal cells of the same tissue type B. Mutation rate of tumor cells is unchanged compared to normal cells of the same tissue type C. Mutation rate in tumor cells is higher compared to normal cells of the same tissue type D. Affected by genome instability within the tumor cells
Which of the following demonstrates the link between oncogenes and cancer? a.Oncogenes do not have mutations that increase the activity or number of molecules that stimulate mitosis. b.Oncogenes produce molecules that inhibit mitosis. c.They are genes that transform tumor cells into normal cells. d.The mutations in oncogenes increase the activity or number of molecules that stimulate mitosis, leading to irregular cell division.
Different gene therapy approaches have been studied for cancer gene therapy. These approaches include? (select all that applies) a.immunotherapy, b. anti-angiogenic gene therapy, c.inhibition of tumor invasion, d.induction of apoptosis
Which of the following steps are correct about multistep tumorigenesis (select all that apply)? A. Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells B. Driver mutations give a cell clone a proliferative advanage C. The rate of mutation /genetic change is constant during tumor progression D. Nutrition/diet may effect rate of tumorigenesis E. All cells within a tumor are biologically equivalent and equally capable of high levels proliferation
Which of the following is NOT an example of fail-safe mechanisms that prevent the irregular cell divisions characteristic of cancer? a.Shortening of telomeres b.Cell division limit c.Mutation in a tumor suppressor gene d.Triggered cell death
Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogene
Which of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)? A. Excessive alcohol consumption that kills liver cells B. Bisphenol A which mimics the activity of estrogen C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB D. Chemical in cigarette smoke that forms adduct with DNA E. A viral infection that causes ulcerative coilitis of GI tract
Which of the following are mechanisms by which cancer drugs work (select all that apply)? A. Inhibit activity of oncogene B. Promote apoptosis C. Promote terminal differentiation of cells D. Inhibit drug transporters E. Promote DNA damage.
Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cells
What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.