When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (select all that apply) a G protein signaling mechanism inside the cell. AG protein signaling mechanism outside the cell. Transporters to uptake degraded neurotransmitters for recyclin The release of neurotransmitter molecules into the postsynaptic
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- A drug binds to a receptor and causes an immediate change in the electrical signaling or excitability of that cell, without activating another signaling molecule. What type of receptor is this drug most likely binding to? G-protein coupled receptor (GPCR) Ligand-gated ion channel Enzyme-coupled receptor Intracellular receptor Voltage-gated ion channelWhich of the following is the best description of how a G protein coupled receptor responds to a ligand binding? O Binding of ligand to the receptor causes the G protein to swap out GTP for GDP Binding of ligand to the receptor causes the G proteins to dimerize and trigger cross-phosphorylation Binding of ligand to the receptor causes the G protein to become activated, then the G protein travels through the plasma membrane to activate an enzyme Binding of ligand to the G protein triggers it to swap out GDP for GTP, causing it to become activated OOO OClassify each phrase as describing ligand-gated ion channels, voltage-gated ion channels, or both. Ligand-gated ion channels a form of passive transport Voltage-gated ion channels include the acetylcholine receptor change conformation in response to changing membrane potential Answer Bank may participate in an action potential Both change conformation in response to a signal molecule binding
- Choose the signaling or type of receptor for eachIntracellular signaling pathways provide multiple opportunities for the amplification of a response to an extracellular signal. Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a True FalseThe figure below shows a signaling pathway activated by the bindiıng of adrehalMNe LU the beta-adrenergic receptor. Binding of adrenaline to the receptor causes GTP-binding and activation of G proteins. Active GTP-bound G protein activates adenylate cyclase to initiate a signaling cascade that affects cellular responses, and includes cellular changes to mediate increased heart rate and accounts for the flight-or-fight response. activated adenylate cyclase adrenaline activated B-adrenergic receptor adenylate cyclase G protein subunit 22 GTP SDP conformational ATP CAMP change in receptor heterotrimeric G protein ACAMP inactive protein kinase A active protein kinase A 4 cellular responses Consider the homozygous mutation in which a cell produces a variant of adenylate cyclase that can no longer be activated Which of the following are true in this cell? Select all that apply. Heart rate increases Protein Kinase A is not activated CAMP levels are lower than normal Heart rate decreases
- Whether the statement "most intracellular signaling pathways provide numerous opportunities for amplifying the responses to extracellular signals" is true or false.Arrange the following in correct order in which G-protein coupled receptor systems are activated: Drug Receptor Protein kinase A Adenylyl cyclase G-protein Cellular responseThe figure below shows a signaling pathway activated by the binding of adrenaline to the beta-adrenergic receptor. Binding of adrenaline to the receptor causes GTP-binding and activation of G proteins. Active GTP-boundG protein activates adenylate cyclase to initiate a signaling cascade that affects cellular responses, and includes cellular changes to mediate increased heart rate and accounts for the flight-or-fight response. activated adrenaline activated B-adrenergic receptor adenylate cyclase adenylate cyclase G protein subunit GTP 3. GDP conformational ATP CAMP change in receptor heterotrimeric G protein ACAMP inactive protein kinase A active protein kinase A cellular responses Consider the homozygous mutation in which a cell produces a variant of the adrenergic receptor that is constitutively active in the absence of ligand. Which of the following are true in this cell? Select all that apply. Protein Kinase A is always activated CAMP concentration is higher than normal Heart rate…
- Compare and contrast signaling via G-protein coupled receptor, receptor tyrosine kinases, nuclear receptor. Please name at least one ligand/receptor for each pathway. Also describe the 'fast' and 'slow' responses mediated by ligand bindingPut the steps of the process of G-protein signal transduction in the order (1-4) in which they occur. Second messenger molecules are activated and amplify the signal A signal molecule binds to a receptor on the outside of the cell The alpha (a) subunit of the G-protein inside the cell moves and binds to a nearby enzyme The receptor changes shape, transducing the signal into the cellThe use of second messengers is an example of a method used in intracellular signaling. (true or false)