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What is MDI? Briefly Discuss the formulation and drug aerosolization process from a MDI? please discuss at your own words.
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- What is DPI? What are the advantages of DPI over MDI? How drug is aerosolized from a DPI system? Please answer at your own words.What is Metered Dose Inhalers(MDI)? Briefly Discuss the formulation and drug aerosolization process from a MDI? Please briefly discuss at your own words.Identify the classification of drug metabolism and specific type of reaction involved in each drugsample. Identify the enzyme involved in each reaction.
- Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity? Identify the classification of drug metabolism and specific type of reaction involved in each drugsample. Identify the enzyme involved in each reaction.What are the potential implications of genetic variations in drug-metabolizing enzymes on individual response and therapeutic outcomes in clinical pharmacology?
- Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…Discuss three types of drug-drug interactions, and explain the links to pharmacodynamics and/or pharmacokinetics, with examples. Give the mechanims.What is more preferred for drug therapy, conventional or modified release dosage forms? Please provide informations that would support the claim.
- As a pharmacist, propose some improvement that can be implemented to further improve the formulation stability. Answer the following case study using your own words.DO NO INC de zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed factors. Order: Monocid 500 mg Supply: Monocid 1,000 mg Directions: Reconstitute with 2.5 mL of sterile water to yield 325 mg/mL Give: mL 4. Moving to another question will save this response. Type here to search EO 9Do not include zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed dosages factors. Order: Rocephin 500 mg IM Supply: Rocephin 1 gram Directions: Reconstitute with 2.1 mL of sterile water to yield 350 mg/mL Give: ML Moving to another question will save this response. Type here to search O E M 90 DELL