which stemenys are false dUnder anaerobic conditions skeletal muscle generates lactate from Pyruvate to regenerate NAD+ for further GlycolysisFor the Pyruvate Kinase reaction the correct sequence of events is substrate level phosphorylation - tautomerization -eketo form of Pyruvate - enol form of PyruvatefDihydroxyacetone Phosphate is an enantiomer of Glyceraldehyde-3-PhosphateCoQ shuttles electrons from Complexl and Il to Complex IVIf [1-1“C] Ribose-5-phosphate is incubated with a mixture of purified transketolase- transaldolase-phosphopentosehisomerase-phosphopentose epimerase and glyceraldehyde-3-phosphate the Erythrose-4-phosphate will be labeled in the1 and 3 positionsiPyruvate Carboxylase activates CO, by ATP through formation of carboxyphosphate as an intermediate

In the case of multiple sub-parts, we answer only the first three sub-parts.To get the remaining…

Answered: Under anaerobic conditions skeletal…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter18: Glycolysis

Section: Chapter Questions

Problem 13P

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Energetic of Fructose-1 ,6-bis P Hydrolysis (Integrates with Chapter 3.) The standard free energy change (G) for hydrolysis of fructose-1. 6-bisphosphate (FBP) to fructose-S-phosphate (F-6-P) and P: is -16.7 KJ/mol: FBP + H2O fructose-6-P + Pi The standard free energy change (G) for ATP hydrolysis is -30.5 KJ/mol: ATP + H2O ADP + Pj What is the standard free energy change for the phosphofructokinase reaction: ATP + fructose-6-P ADP + FBP b. What is the equilibrium constant for this reaction? c. Assuming the intracellular concentrations of [ATP] and (ADP] are maintained constant at 4 mM and 1.6 mM, respectively, in a rat liver cell, what will be the ratio of [FBP]/[fructose-6-P] when the phosphofructokinase reaction reaches equilibrium?
Radiotracer Labeling of Pyruvate from Glucose Determine the anticipated location in pyruvate of labeled carbons If glucose molecules labeled (in separate experiments.) with 14C at each position of (.tie carbon skeleton proceed through the glycolytic pathway.
Which reaction below in the glycolytic pathway has a highly unfavorable delta Gº' but a favorable delta G under physiological conditions? 1,3-Bisphosphoglycerate + ADP3-Phosphoglycerate + ATP O2-phosphoglyerate → phosphoenolpyruvate Ofructose-1,6-bisphosphate dihydroxyacetone phosphate + glyceraldehyde-3-phosphate Ofructose-6-phosphate → fructose-1,6-bisphosphate
HANDOUT C Glucose-6 Phosphate Dehydrogenase and TPI Deficiencies Glucose-6-P GSH + GSH Reduced glutathione 2 H+ NADP+ H₂O₂ Hydrogen peroxide Glucose-6-phosphate dehydrogenase Superoxide radical NADPH + H+ 6-Phosphogluconolactone GSSG Glutathione Oxidized reductase Glutathione peroxidase Aerobic respiration, drugs, fava beans glutathione 2 H₂O Detoxification SOD: superoxide dismutase GPx: glutathione peroxidase HK: hexokinase GSSG and GSH: glutathione, oxidized and reduced forms, respectively CAT: catalase The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis- rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed in liver cells, red blood cells, and in lipid-producing tissues. 1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your response. 2. How does this effect differ from TPI patients? 3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
Handwritten Identify the molecule names, enzyme name, enzyme classification and change in reaction(for glycolysis pathway)
Palmitoleic acid, 16:1Δ⁹ hexadecaenoic acid, (16 carbon FA with one double bond )is an important fatty acid component of TAGs and cell membranes. Briefly explain the process of beta oxidation of this fatty acid and the number (only) of FADH, NADH and acetyl CoA outcome. What is the total ATP (only number) generated from this fatty acid after beta oxidation.
Draw the products of the reaction of xylulose-5-phosphate and erythrose-4-phosphate catalyzed by transketolase in the pentose phosphate pathway. Provide the structure in the protonation state found in physiological conditions. H H H OH FO HO-H H-OH H OPO3²- Q transketolase Draw glyceraldehyde-3- phosphate H H- H H H O OH OH OPO3²- Draw fructose-6- phosphate Q I I
The intermediates of glycolysis with a free energy of hydrolysis sufficient to couple conversion of ADP + phosphate to ATP (a substrate level phosphorylation) include (Choose all that apply) O phosphoenolpyruvate O 2-phosphoglycerate O 1,3-bisphosphoglycerate O glucose-6-phosphate. O fructose-6-phosphate. O fructose-1,6-bisphosphate. O dihydroxyacetone phosphate
The glyceraldehyde-3-phosphate-deshydrogenase glyceraldehyde-3-phosphate in 1,3-bisphosphoglycerate. catalyses the catalyses -CH₂ -CHOH—CHO + Pi + NAD* the oxidation of CH₂ CHOH-COQ + H* + NADH When the enzyme is incubated with iodoacetate, it is observed that glyceraldehyde-3- phosphate still binds to the modified enzyme, but it is not oxidized. What conclusion can be drawn from this experiment? Data: iodoacetate ICH₂COO is an alkylating reagent that react with free sulfhydryl groups (-SH) to form (-S-CH₂COO).
Briefly explain the malate-aspartate shuttle. Distinguish between this shuttle with the glycerol -phosphate shuttle based upon their transport of reducing equivalents and their potential for ATP synthesis.
Choose the enzyme and cofactors involved in the reaction of fructose-1,6-bisphosphate to fructose-6-phosphate in gluconeogenesis. H H-TOPO Fo HOTH HDH HOH MOTOPOP K E H-TOH H OPO Problem 3 of 17 A B Q D E fructose-1,6-bisphosphatase phosphoglucose isomerase glucose-6-phosphatase phosphoglycerate kinase hexokinase
Although phosphoesters are generally not energetic enough to donate the phosphate to make a high energy bond (e.g., a phosphoanhydride), the phosphate in PEP is used to convert ADP to ATP in the pyruvate kinase reaction. Carefully explain the ‘quirk’ of this reaction that makes it energetically feasible.

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