Typical pharmacokinetic parameters for drug-A are: P-0.1, fex<0.1 fu-0.9: CL 0.32 L/hr/kg; Half-life 6 hr When an IV-bolus (Dose 450 ma) is administered to a 54 kg patient every 6 hours, the maximum plasma concentration at steady state is ma/L (round to nearest tenth) nswer 1-1
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- A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume of distribution 18 L. • Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6 mg/L for 8 hours. What is the initial plasma concentration? (C) • What is half life of this drug? (t1/2) Please select one: a.C-16.5 mg/L t1/2=5 h b.C=14 mg/L 11/2=2.5 h c.C=17.5 mg/L 11/2=3 h d.C=20.6 mg/L t1/2=5 h e.C-18.4 mg/L t1/2=5 hA 129.8 pound patient was prescribed an oral antidepressant. The medication was prescribed as 50 mg PO Q8 H. This antidepressant has a 10.4 hour elimination half-life, a 0.8 L/kg volume of distribution, a 30.7% oral bioavailability, and a 1.5 hour absorption half-life. What is the average steady state drug concentration of the antidepressant in this patient? NOTE: Please provide your answer in units of µg/L. Do not include units in your answer.The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.
- You are requested to recommend a dosage regimen for a patient (5S years old, 80 kg) to achieve plasma levels of 25 mg/L of an antiepileptic agent with an elimination half-life of 11 hrs and an apparent Vd of 0.02 L/kg. The tablets are 75% bioavailable and are available as 10 mg and 40 mg tablets. The ideal dosage regimen for this patient is: 10 mg twice daily 10 mg four times a day 40 mg daily 40 mg twice dailyAnalgesia plan for a cat with urinary obstruction: Buprenorphine (for pain) 4.54kgx0.03mg/kg =0.1362mg÷0.3mg/ml=0.45ml Meloxicam (Anti-inflammatory): 4.54 kg x 0.3 mg/kg = 1.3662 mg ÷ 5 mg/ml = 0.27 ml * Please calculate for 4 days, since the cat will remain in the hospital for 4 days.A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mL
- Calculate how much you need for the following dosages 36 You have haloperidol injection 5 mg in 1 mL; amount required = 6 mg. 37 You have diazepam suspension 2 mg in 5 mL; amount required = 5 mg. 38 You have codeine phosphate syrup 25 mg in 5 mL; amount required = 30 mg. 39 You have co-trimoxazole injection 480 mg in 5 mL; amount required = 2,040 mg. What volume and how many ampoules do you need?A C D B Log drug dose CENTR O In reference to this figure, compare the 4 drugs as to (1) efficacy and SENTE (2) potency. UNIVERSITY WRITE ANSWER AFTER THIS LINE: (1) Based on efficacy (2) Based on potency ResponseDo not include zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed dosages factors. Order: Rocephin 500 mg IM Supply: Rocephin 1 gram Directions: Reconstitute with 2.1 mL of sterile water to yield 350 mg/mL Give: ML Moving to another question will save this response. Type here to search O E M 90 DELL