The steroid nandrolone, which is found naturally in horses, is administered to racing horses to aid in recovery. Because it is ananabolic steroid, nandrolone levels in excess of normal background levels disqualify a horse from racing. For example, to race inthe Kentucky Derby, a gelding (a castrated male horse) may have no more than 1 ng/mL in the urine, whereas an unaltered malehorse may have no more than 45 ng/mL of the metabolite estrane-3,17-diol in the urine.Knowing that nandrolone is an anabolic steroid, whichhormone would you expect it to closely resemble?(testosteronecortisolO progesteroneO epinephrineantidiuretic hormoneDuring metabolism, carbon 3 and carbon 4 of nandrolone are reduced, forming the metabolite estrane-3,17-diol. Modifynandrolone to give estrane-3,17-diol.SelectDrawRingsMoreEraseSс O0H✪ا قد2o

Nandrolone is a steroid that is both anabolic and androgenic. It is formed from an estrane's…

Answered: The steroid nandrolone, which is found…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for males
An athlete tested positive for Methylhexaneamine in urine with a level of 0.90 µg/mL. At her appeal in the Court of Arbitration, she quotes a highly respected scientific publication that states that at levels of 1.0 µg/mL there is no performance enhancement. If the athlete’s levels are indeed below this threshold, the athlete can face a year’s suspension instead of a ban for life. Use the Estimate of Uncertainty to determine if the Athlete should be given a 1 year suspension or banned for life.
A two-month old child was admitted to hospital after failure to thrive. The “boy”, whose external genitalia were ambiguous, was found to have elevated blood pressure, but no dehydration. The following measurements were made on a plasma sample taken on admission: Variable Result Reference Range Urea (mM) 6.2 2.5 - 7.0 Creatinine (μ�M) 95 60 - 120 Glucose (mM) 4.3 3.5 - 5.5. (fasting) Na+ (mM) 170 134 -147 K+ (mM) 2.8 3.5 - 5.0 11 -deoxycortisol (nM) 57 <10 Deoxycorticosterone (nM) 1.3 <0.4 Cortisol (nM) 22 138 - 690 Testosterone (nM) 7.4 0.5 -3.2 (adult female) 5 - 40 (adult male) The concentrations of progesterone, 17-hydroxyprogesterone and ∆4-androstenedione were also increased above the reference range. A chromosome analysis showed that the child was a genotypic female (46, XX karyotype). A consultant obstetrician initially diagnosed congenital adrenal hyperplasia, however they were confused by the…
A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
1.8 Which of the following is likely to cause the kidney to change the reabsorption of water and/or NaCl? Select one: a. Drinking 1 L of water in a short period of time. (Assume that you weren't dehydrated.) b. Eating a big bag of salty potato chips. c. Forgetting to drink water all day. d. Exercising vigorously in a very hot environment. e. All of the above
Sarah who weighs 67 kg is to receive acetylcysteine at a dose of 50 mg/kg infused over 4 hours for paracetamol overdose. The required volume of concentrated acetylcysteine solution (200 mg/mL) has been added to 500 mL of 5% glucose solution. What is the concentration of the solution to be infused (mg/mL)? (Answer to 1 decimal place.) Answer: 16.75 mg x
A 79 kg man is admitted to hospital following a suspected overdose of drug G. When he is admitted to hospital on the 3rd October at 23:00 his plasma concentration of drug G is 12 mg/mL. Given that the half-life (t½) of drug G is 10.5 hours. What would you expect his plasma concentration of drug G to be at 17:00 on the 5th October? Give the answer in microg/ml. (You may assume that the distribution is complete and the elimination is described by a 1storder process.)
Briefly explain these three facts:
When the drug theophylline is administered for asthma, a concentration below 5 mg/L has little effect and undesirable side-effects appear if the concentration exceeds 20 mg/L. For a body that weighs W kg, the concentration when M mg is present is 2M/W mg/L and the constant that measures the rapidity at which the concentration falls is T = 6 h. If a 500-mg tablet of the drug is taken by a person weighing 70 kg, after how many hours should the second dose be taken so as to prevent the drug from falling below the effective concentration? About 6 hours Once a day About 12 hours O About 8 hours
A physician orders lidocaine 100 mg in D5 How many drops per minute will be administered? sgad to ini yasm voH A physician orders epinephrine 50 mcg/min to be administered from fluids that contain epinephrine 5 mg in D5LR 500 mL. The drop factor is 20 gtt/mL. How many minutes will it take for the fluids to infuse? What is the rate of infusion in drops per minute? What is the flow rate in milliliters per hour? after 300 mL had infused? Luhte reserved.
A child is ordered an infusion of cytarabine 200 mg/m2 in 0.9% NaCl to infuse over 24 hours. If the child weighs 22.7 kg and is 120 cm, how many mg of cytarabine would you add to the 9% NaCl?
Womersley number (a) of a human aorta is 20 and for the rabbit aorta is 17, the blood density is approximately the same across the species. The values of viscosity were 0.0035 Ns/m² for the human and 0.0040 Ns/m² for the rabbit. The diameter of the aorta is 2.0 cm for the man, and 0.7 cm for the rabbit, estimate the heart rate beats per minute (bpm) for both species.

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