Small, monomeric G-proteins differ from trimeric G-proteins in that monomeric G- proteins .. a) are downstream components of receptor tyrosine kinase (RTK) pathways rather than GPCR-mediated pathways. b) lack GTPase activity, therefore need a separate enzyme to turn themselves off. O c) inactivate themselves via intrinsic GTPase activity. O d) activate adenylyl cyclase, which in turn increases intracellular cyclic AMP concentrations. are active when bound to ATP rather than GTP.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Small, monomeric G-proteins differ from trimeric G-proteins in that monomeric G-
proteins ...
a) are downstream components of receptor tyrosine kinase (RTK) pathways rather
than GPCR-mediated pathways.
O b) lack GTPase activity, therefore need a separate enzyme to turn themselves off.
c) inactivate themselves via intrinsic GTPase activity.
d) activate adenylyl cyclase, which in turn increases intracellular cyclic AMP
concentrations.
e)
are active when bound to ATP rather than GTP.
Transcribed Image Text:Small, monomeric G-proteins differ from trimeric G-proteins in that monomeric G- proteins ... a) are downstream components of receptor tyrosine kinase (RTK) pathways rather than GPCR-mediated pathways. O b) lack GTPase activity, therefore need a separate enzyme to turn themselves off. c) inactivate themselves via intrinsic GTPase activity. d) activate adenylyl cyclase, which in turn increases intracellular cyclic AMP concentrations. e) are active when bound to ATP rather than GTP.
What would happen if a mutant Ras protein was unable to release GDP and bind GTP?
The associated RTK receptor could not become phosphorylated after ligand
O a)
binding.
The proteins downstream from Ras would not be activated and downstream
O b)
signaling would be blocked despite binding of the ligand to the receptor.
The proteins downstream from Ras would not be produced, and would not be
present in the cell.
d) The cell would become cancerous.
O e) The associated RTK receptor could no longer bind its signal molecule.
Transcribed Image Text:What would happen if a mutant Ras protein was unable to release GDP and bind GTP? The associated RTK receptor could not become phosphorylated after ligand O a) binding. The proteins downstream from Ras would not be activated and downstream O b) signaling would be blocked despite binding of the ligand to the receptor. The proteins downstream from Ras would not be produced, and would not be present in the cell. d) The cell would become cancerous. O e) The associated RTK receptor could no longer bind its signal molecule.
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