Question 5 Furosemide is a diuretic used in the treatment of congestive heart failure and oedema. 20 tablets of furosemide were powdered and 0.5195 g of powder was weighed out, shaken with 300 mL of NaOH and made up to 500 mL with 0.1 M NaOH. A portion of the extract was filtered and 5 mL of the filtrate was made up to 250 mL with 0.1 M NaOH. The absorbance of the diluted solution was measured at 271 nm. A (1%, 1 cm) value at 271 nm in basic solution Stated content of furosemide Weight of 20 tablets per tablet HN- From the data below calculate the percentage of stated content in a sample of furosemide tablets. (DGW 2005, 103) = 580 = 40 mg = 1,656 g OH NH

Question 5 Furosemide is a diuretic used in the treatment of congestive heart failure and oedema. 20 tablets of furosemide were powdered and 0.5195 g of powder was weighed out, shaken with 300 mL of NaOH and made up to 500 mL with 0.1 M NaOH. A portion of the extract was filtered and 5 mL of the filtrate was made up to 250 mL with 0.1 M NaOH. The absorbance of the diluted solution was measured at 271 nm. A (1%, 1 cm) value at 271 nm in basic solution Stated content of furosemide Weight of 20 tablets per tablet HN- From the data below calculate the percentage of stated content in a sample of furosemide tablets. (DGW 2005, 103) = 580 = 40 mg = 1,656 g OH NH