Question 1: In the early 1960s, retroviruses were determined to cause many avian cancers. As a result, nucleic acid analogs as potential antiviral compounds were tested against various human cancer cells. Since this retrovirus theory did not pan out in human cancers, many potential drugs were shelved. However, in the 1980s, a new retrovirus, HIV, became a major focus of drug discovery, or re-discovery in this case. Zidovudine, or 5-azidothymidine (AZT), was found to be a very potent inhibitor of HIV, and quickly became an indispensable part of HIV treatment, and remains so to this day. AZT works by being incorporated into a new viral DNA chain. However, the N3 group (an azide group) prevents the next connection, effectively stopping the DNA synthesis. Assign all stereocenters as R or S. C HO to product dist Huon NH N= .... AZT 5-azidothymidine oxyge tee as can

Question 1: In the early 1960s, retroviruses were determined to cause many avian cancers. As a result, nucleic acid analogs as potential antiviral compounds were tested against various human cancer cells. Since this retrovirus theory did not pan out in human cancers, many potential drugs were shelved. However, in the 1980s, a new retrovirus, HIV, became a major focus of drug discovery, or re-discovery in this case. Zidovudine, or 5-azidothymidine (AZT), was found to be a very potent inhibitor of HIV, and quickly became an indispensable part of HIV treatment, and remains so to this day. AZT works by being incorporated into a new viral DNA chain. However, the N3 group (an azide group) prevents the next connection, effectively stopping the DNA synthesis. Assign all stereocenters as R or S. C HO to product dist Huon NH N= .... AZT 5-azidothymidine oxyge tee as can

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter22: Organic And Biological Molecules

Section: Chapter Questions

Problem 160CP

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