Propose a Furka Combine, Mix and Split approach for the solid phase synthesis shown below. H₂CO₂C Bead X₁ = F X₂ = Cl X3 = Br H₂ Pd/C H3C- X ZO₂C YN3 N=N be #per N=N H3CO₂C Y₁ = CH3 Y₂ = CF3 Y3=CCI3 ZOH acid heat N=N Z₁ = CH3 Z₂ = CH₂CH3 Z3=CH₂CH₂CH3

Chemistry
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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Propose a Furka Combine, Mix and Split approach for the solid phase synthesis
shown below.
YN3
ZOH
N=N
acid
heat
N=N
H3CO2C
H3CO2C
ZO,C
X, = F
X2 = CI
X3 = Br
Y, = CH3
Y = CF3
Y3 = CCI3
Z = CH3
Z = CH,CH3
Z3 = CH,CH,CH3
Bead
H2
H3C-
Pd/C
N=N
ZO2C
List advantages/disadvantages that a Furka solid phase method has over a
conventional solid phase method.
Transcribed Image Text:Propose a Furka Combine, Mix and Split approach for the solid phase synthesis shown below. YN3 ZOH N=N acid heat N=N H3CO2C H3CO2C ZO,C X, = F X2 = CI X3 = Br Y, = CH3 Y = CF3 Y3 = CCI3 Z = CH3 Z = CH,CH3 Z3 = CH,CH,CH3 Bead H2 H3C- Pd/C N=N ZO2C List advantages/disadvantages that a Furka solid phase method has over a conventional solid phase method.
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