Platelets from a patient with long bleeding times are tested in vitro and shown to display reduced adhesion and aggregation responses to collagen. What mechanisms could account for the altered in vitro responses and haemostaticn phenotype this is from a past paper but i couldnt find an example answer

Platelets from a patient with long bleeding times are tested in vitro and shown to display reduced adhesion and aggregation responses to collagen. What mechanisms could account for the altered in vitro responses and haemostaticn phenotype this is from a past paper but i couldnt find an example answer

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 5CT: Some desperate cancer patients consume pills or other preparations containing shark cartilage, which...

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Some desperate cancer patients consume pills or other preparations containing shark cartilage, which the manufacturers tout as an anti-angiogenesis compound. The basis for these claims is the fact that blood vessels do not grow into cartilage. Responsible researchers point out that, regardless of the properties of cartilage, there is no way that eating it could provide any anticancer benefit. Why is this counterargument correct?
You are growing up myoblasts, C2C12 cells, to use in a myogenic study. You are using T-150 flasks with a culture area of 150 cm2 and when confluent contains 2 x 107 cells. 2) You seed a culture of squamous epithelial cells at 8 am on Monday with 1.2 x 105 cells. The next day at 8 am you harvest the cells. You know from past studies that the generation time is 26 hours for this cell line. How many cells do you predict you should have on hand? A) 1.64 x 10^5 cells B) 4.56 x 10^3 cells C) 5.23 x 10^10 cells D) 1.75 x 10^8 cells E) None of these
It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…
T/F Type I collagen fibers, that consist of collagen triple helices aligned side-by-side, are strengthened by covalent cross-links between amino acid side chains of different collagen triple helices. True O Failse
You are growing up myoblasts, C2C12 cells, to use in a myogenic study. You are using T-150 flasks with a culture area of 150 cm2 and when confluent contains 2 x 107 cells.You are growing up myoblasts 3)You seed another culture of a different end cell line, john12 cells at 8am on Friday with 104 cells. By Thursday at noon (12:00pm) they reach confluence. Assume the same confluency as stated above for T150 flask. What is the generation time (doubling time)
You are growing up myoblasts C2C12 cells,to use in a myogenic study,You are using T-150 flasks with a culture area of 150 cm2 and when confluent contains 2*107 cells. you seed a culture at 8 am on Monday with 5*105 cells .Assume all survive a generation time of 18 hrs and all cells are actively dividing.when will you expect them to be confluent?
(e) Two ADP agonists (drugs) were also found to bind to platelets: 2-methylthio-ADP bound with a Kp of 7 µM and 2-(3-aminopropylthio)-ADP bound with a Kp of 200 µM. Can these drugs effectively compete with ADP for binding to platelets? Explain your answer.
Describe the major activity and possible localization of the three major subgroups of proteins that remodel or degrade the ECM in physiological or pathological tissue remodeling. Identify a pathological condition in which these proteins play a key role.
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A research study investigates the synthesis of filaggrin-containing granules in skin biopsies from patients of atopic dermatitis. Which of the indicated layers is the site for these granules? Answers A - E AA B B C C D D EE O O O Question #44 attachment <-A B -C -D E
Cell adhesion molecules (CAMs) can form cis and trans interactions with other CAM molecules. True or False
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