Pernicious anemia. Purine biosynthesis is impaired by vitamin B12 B12 deficiency. Why? How might fatty acid and amino acid metabolism also be affected bya vitamin B12B12 deficiency?
Q: disease. As such, a frontline treatment for Type 2 diabetes is the drug metformin, which acts…
A: Hi! Thanks for your question. As you have posted multiple questions, we are answering the first…
Q: . In Figure 6-11,a. in view of the position of HPA oxidase earlier in thepathway compared to that of…
A: Alkaptonuria is defined as a rare and unique genetic and metabolic disorder that is characterized by…
Q: Mechanism of C1,C2-diether and C2-monoether derivatives of lycorine with explanation
A: Lycorine is an alkaloid compound with natural properties for inhibiting the disease called as dengue…
Q: The malate aspartate shuttle plays many roles in carbohydrate and amino acid metabolism. Malate can…
A: 1The malate aspartate shuttle plays many roles in carbohydrate and amino acid metabolism. Malate can…
Q: Amino AcidMetabolism. a. What are the SIXprecursors used in amino acid biosynthesis? b. What are…
A: Amino acids that are synthesized in the body are known as non-essential amino acids. The amino acids…
Q: . Unsaturated fatty aids readily undergo radical-mediated peroxidation. Describe the propa- gation…
A: Cells produce many free radicals as a result of various metabolic reactions. The free radicals are…
Q: The interconversion of DHAP and GAP greatly favors the formation of DHAP at equilibrium. Yet the…
A: GAPDH has a high affinity for DHAP, thus pushes TIM reaction towards GAP formation.
Q: ACTIVITY-1. Which of the following is NOT a monosaccharide? Explain your reasoning. A C D но. ÇH2OH…
A: Monosaccharides are carbohydrates. Carbohydrates are macromolecules which are made up of carbon,…
Q: Serine protease enzyme mutation To show differences in the effect of the nucleophilic attack of…
A: Mutations in enzyme lead to serious or fatal disorders in humans and are the consequence of…
Q: The biochemical pathway impacted by your disease Congential Adrenal Hyperplasia that shows the name…
A: The group of an inherited genetic disorder that is characterized by the defect of the adrenal gland…
Q: b-Oxidation of naturally occurring monounsaturated fattyacids requires an additional enzyme. What is…
A: Beta-oxidation is the catabolic process by which fatty acid molecule are broken down in the cytosol…
Q: a) List and draw the structure of this coenzyme. Which of the coenzymes required by the PDH does…
A: The given molecular analogue name is Thiamine thiazolone pyrophosphate. It is a transition state…
Q: A- Explain why freshly produced palmitate (palmitic acid) from fatty acid synthesis is not directly…
A: Fatty acid synthesis is the conversion of fatty acids from acetyl CoA and NADPH through the action…
Q: Describe the β-oxidation of the fatty acid palmitate
A: Beta oxidation in biochemistry and metabolism is a catabolic process through which fatty acid…
Q: (a) Explain why fluorescence spectroscopy gives a more accurate determination of vitamin B1 than…
A: Since you have asked multiple questions, we will solve the first question/part 1 for you. If you…
Q: formation? thrombin; fibrinogen prothrombin; fibrin → fibrinogen fibrinogen; thrombin - fibrin;…
A: We are authorized to answer one question at a time, since you have not mentioned which question you…
Q: Molecular detail of spike Y453F
A: Spike proteins play a vital role in however these viruses infect their hosts. See all our coverage…
Q: The negative impact of PKU can be reduced by stimulation of alternative pathways of phenylalanine…
A: All the genes in the body are present in the DNA of the cell. these genes are a triplet codon of…
Q: A- Explain why freshly produced palmitate (palmitic acid) from fatty acid synthesis is not directly…
A: Biosynthesis of fatty acids occur in the cytosol unlike the beta oxidation pathway in the…
Q: Just obeying the laws. Why do isolated F1F1 subunits of ATP synthase de catalyze ATP hydrolysis?
A: Enzymes (biological catalysts) increase the speed of biochemical reactions. The molecule on which…
Q: Pharmacokinetics of cyclophosphamide
A: Pharmacokinetics is the term which describes the process that what our body does to a drug when the…
Q: Working at cross-purposes? Gluconeogenesis takes place during intense exercise, which seems…
A: Glucose is a ubiquitous sugar compound found in various food sources such as fruits, honey, etc.…
Q: Why bother to eat? What are the three primary uses for cellular energy?
A: Eating healthy and balanced provides the right amount of nutrients to your body, which is a key…
Q: Suggest a reason why sugar nucleotides, such as UDPG, play a role in glycogen synthesis, rather than…
A: Glycogenesis is the process of synthesis of glucose which was regulated by several enzymes and…
Q: Insulin-dependent diabetes is often accompanied by hypertriglyceridemia, which is an excess blood…
A: Lipoproteins are lipid/protein particles that are responsible for the transport of lipids in the…
Q: Degradation of normal glycogen results to 97.2% glucose 1-phosphate and 7.2% glucose. Assuming a…
A: A disease is an abnormal state of an organism that disrupts biological processes. It might be acute,…
Q: ATP yield. Each of the following molecules is processed by glycolysis to lactate. How much ATP is…
A: The glycolysis process is known to occur both aerobic and anaerobically. In the absence of oxygen,…
Q: explain how α-tocopherol and ascorbate work together in suppressing the oxidation of polyunsaturated…
A: Polyunsaturated fatty acids (PUFA) are fatty acids that contain more than one double bond in their…
Q: - The mitochondrial form of carbamoyl phosphate synthetase is allosterically activated by…
A: N-Acetyglutamate acts as an allosteric activator of carbomyl phosphate synthase.
Q: 3. Protection of Enzyme Against Denaturation by Heat When enzyme solutions are heated, there is a…
A: Enzymes are protein molecules that increase the rate of reaction by decreasing the activation energy…
Q: Regulatory enzymes are crucial for the proper functioning and coordination of glycolysis and…
A: Introduction: Enzymes are the biological catalysts that increase the rate of a chemical reaction…
Q: Insulin dependent diabetes is often accompanied by high levels of triacylglycerols in the blood.…
A: Triglycerides are 3 esters of glycerol which was bound to three fatty acid molecules. where they are…
Q: ATP ACCOUNTING, Provide what is being asked for. Show all relevant calculations and summarize your…
A: Hydrolization of lactose gives the galactose and glucose moieties. Galactose is converted to…
Q: True/Flase? Substrate level phosphorylation is a process that produces ATP and other nucleoside…
A: Phosphorylation means the attachment of the phosphate group directly to the target molecule. ATP…
Q: Isopentyl pyrophosphate (activated isoprene) undergoes cyclization during cholesterol biosynthesis.…
A: a. Cholesterol is the major sterol present in animal tissues. b. The major site for fatty acid…
Q: Lysozyme’s use of aspartic acid and glutamic acid, to break the glycosidic bonds of the eubacterial…
A: The eubacterial cell wall is composed of the peptidoglycan which is a giant molecule surrounding the…
Q: activity? To answer the question: a) name the hormone, controlling the lipid metabolism in…
A: The breakdown or storage of fats for energy, as well as the production of structural and functional…
Q: C- The combination of cholestyramine and an inhibitor of HMG CoA reductase is very in reducing serum…
A: Familial Hypercholestrolemia is caused due to high level of LDL Cholestrol (LDL-C). HMG CoA…
Q: Question:- Explain why withholding galactose from the diet of galactosaemia patients has no effects…
A: The oligosaccharides are produced in the endoplasmic reticulum and are transported to the protein…
Q: Briefly explain why chicken fat, which largely consists of various triacylglycerols, has such a…
A: Lipid is an essential biomolecule. like phospholipid, triglycerides, sterols are part of it .…
Q: the major biochemical function of B vitamins within the human body is as:
A: Vitamins are a group of substances that are required for normal cell function, development, and…
Q: using specific examples explain the biochemical significance of saturated and unsaturated fatty…
A: Our body needs energy for the proper functioning of all the organs and to sustain the metabolic…
Q: Multivitamin B complex are essential compounds that are used as derivatives for compounds necessary…
A: The B complex vitamins are water-soluble vitamins and act as a precursor of coenzymes, required for…
Q: The most common form of malnutrition in children in the world, kwashiorkor, is caused by a diet…
A: Effect on high level of insulin on: 3.1% lipid utilization: An insulin level get increased it…
Q: Etiology? What does that mean? What does the fact that rotenone appears to increase the…
A: Etiology- Parkinson's disease is a progressive nervous system disorder that affects movement.…
Q: β-Oxidation of naturally occurring monounsaturated fatty acids requires an additional enzyme. What…
A: Fatty acids are defined as carboxylic acids having long aliphatic chains that can be either branched…
Q: The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe…
A: Alloprinol is structural analog of the natural purine base , hypoxanthine. Hypoxanthine is an…
Q: The Payoff Phase of Glycolysis in Skeletal Muscle In the skeletal muscle, in anaerobic conditions,…
A: Glucose is converted into pyruvate by a series of ten biochemical reactions. This biochemical…
Q: Enzyme Activity and Physiological Function, The Vmax of the enzyme glycogen phosphorylase from…
A: Glycogen Phosphorylase It is a major enzyme of Glycogenolysis that breaks glycogen and releases…
Q: help with filling in the blanks The amino acid [alanine/aspartate/glutamate] can be…
A: Glucogenic amino acids are the amino acids which acts as the precursor of gluconeogenesis…
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- Fill in the blanks. Acetaminophen toxicity can occur at high doses in the liver. because ___________ (what type of molecules?) can become saturated and other routes of metabolism take over.Please explain to me what the correct molecule(?) is and why it is correct. I understand that the glucuronidation and sulfation conjugation pathways become saturated, but am not understanding what molecule(s) it is/are that is/are becoming saturated leading to the other routes of metabolism and acetaminophen toxicity.Draw Gluconeogenesis. Please make sure to state all the enzymes and co-factors for each step of the pathway.Closely related. Pyruvate dehydrogenase complex and a-ketoglutarate a-ketoglutarate dehydrogenase complex are huge enzymes consisting of three discrete enzymatic activities. Which amino acids require a related enzyme complex, and what is the name of the enzyme?
- Sources of Glucose during Starvation. The typical human adult uses about 160 g of glucose per day, 120 g of which is used by the brain. The available reserve of glucose (~20 g of circulating glucose and ~190 g of glycogen) is adequate for about one day. After the reserve has been depleted during starvation, how would the body obtain more glucose?Need help, please. For the scenario below relating to Glycogenolysis, please explain how glucose release would be affected. Would it increase, decrease, or result in no change when compared to “normal” conditions? In addition, please identify which enzyme or reaction is affected and why. Scenario: free inorganic phosphate is chelatedThey are everywhere. What energetic barrier prevents glycolysis from simply running in reverse tosynthesis glucose? What is the energetic cost to overcome this barrier?
- BIOCHEMISTRY. Could glycerol be used to regenerate the OAA for maintenance of TCA cycle activity? Yes or No? Explain.Amino AcidMetabolism. a. What are the SIXprecursors used in amino acid biosynthesis? b. What are the SEVEN metabolic intermediates that result from amino acid degradation? c. Circle the metabolites found in your answers to both a) & b) above. d) What is the difference between glucogenic and ketogenic amino acids? List the glucogenic amino acids, the ketogenic amino acids & the amino acids that are both glucogenic & ketogenic.Draw Gluconeogenesis. Please make sure to state all the enzymes and co-factors for each step of the pathway. note you are responsible for all the enzymes for each step, even though it is not stated on the slide.
- Help filling in the blanks: The malate aspartate shuttle plays many roles in carbohydrate and amino acid metabolism. Malate can be transferred into the cytosol and interconverted in one enzymatic step to produce [oxaloacetate/glucose/PEP/pyruvate] for use in the pathway of [glycolysis/gluconeogenesis]. A product of the urea cycle, derived from aspartate, can also be converted to malate in one enzymatic step and shuttled into the mitochondria so that the urea cycle product can be used in [fatty acid synthesis/the citric acid cycle/β-oxidation]. The amino group from aspartate can be transferred to [oxalacetate/malate/fumarate/pyruvate/a- ketoglutarate] to form glutamate, which is then transported into the mitochondria. In fact many amino acids are transaminated in this way to form glutamate in the cytosol. In this way, incoming amino acids from the bloodstream can be shuttled into the liver mitochondria as glutamate for conversion by glutamate dehydrogenase to [glutamate/a-ketoglutarate…disease. As such, a frontline treatment for Type 2 diabetes is the drug metformin, which acts indirectly to inhibit gluconeogenesis in the liver. You are a research biochemist who would like to develop new drugs that act to directly inhibit gluconeogenesis. You have just gained access to a library of thousands of small molecules of unknown activity, and you would like to identify lead compounds that have specific inhibitory activity against steps in the gluconeogenesis pathway. (a) into PEP in order to screen for inhibitors of enzymes specific to gluconeogenesis. Which enzymes do you need to purify, what cofactors and allosteric effectors do they require, and which reactants do you need to add to reconstitute the reactions for the first bypass? Which intermediates and products are generated? Your first approach is to reconstitute the initial set of bypass reactions that convert pyruvate (b) vitro reconstitution? What additional steps and enzymes are required in liver cells but are…- Keto counterparts. Name the a-ketoacida-ketoacid that is formed by the transamination of each of the following amino acids: Co, a. Alanine b. Leucine c. Aspartate d. Phenylalanine e. Glutamate f. Tyrosine