Pedigree 4: A. What mode of inheritance supports the pattern of this disease in this family? Choose from: autosomal dominant or autosomal recessive. B. State the genotypes of individuals #1 - #4 for this mode of inheritance. C. Ifindividual #3 has another child with the same partner, what is the probability that this child will have the disease?
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- b. The following diagram shows a family tree of individuals with haemophilia. B i. Based on an X-linked recessive pattern of inheritance, work out the likely genotypes of the individuals indicated by the letters. Individual A Individual B Individual C GENOTYPE ii. If individual C has children with a normal male, what are the chances that they will have haemophilia? Explain your answer fully. iii. If individual C has children with a normal male, what are the chances that their daughters will be carriers of the condition? Explain your answer fully.Explain the following1. A couple comes to a genetic councilor concerned about their chances of having a baby with cystic fibrosis disease. The husband had a sibling die of the disease. What are the chances that he is a carrier?2. STATEMENT: A woman and man both do not have sickle-cell anemia, but both had one parent who had sickle cell. Sickle-cell is an autosomal (somatic) recessive trait. a) What is the genotype for the woman, man and each of their parents? b) This couple unexpectedly is going to have their first child. i. What's the probability that their child will have not have sickle cell like the couple? ii. What's the probability that the child will have sickle cell like one the grandparents?
- 3. D. A. B. C. 10. Familial hypercholesterolemia is the most common genetic cause of heart disease. It is caused by a dominant factor (C). The recessive factor (c) produces a protein that processes cholesterol normally and leads to a normal risk for heart disease. Answer the following questions about the inheritance of this disease. What is the phenotype of a woman whose genotype is Cc? What is the genotype of a man who has hypercholesterolemia but whose mother did not have the disease? If a man who is heterozygous for the disease marries a woman who is heterozygous for the disease, what is the chance that any child of theirs will inherit the disease? If a man who is homozygous dominant marries a woman who is homozygous recessive, what would you predict for the the genotypes and phenotypes of their children? If the first 2 children from the marriage described in D above have the disease, what is the chance that a third child would be normal? Explain your answer. 41Pedigree 2: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B State the genotypes of individuals # 1 #4. C If individual #3 has another daughter with the same partner, what is the probability that this daughter will be affected (show the disease)?А. I. For A and B, 1. Identify the type of inheritance. Justify your answer. 2. Decode the genotypes of the individuals in pedigree. (Use for the letter A representation alleles.) of 2 3. List down all affected II individuals. 1 6 7 8 2 4 II 1 2 3 4 5 6 7 8 9 3. B.
- II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) Autosomal recessive and b) Autosomal dominant in order to determine what is the mode of transmission of this trait. Disease allele = a or A, depending on mode of transmission of the disease respectively. Your Punnett squares should reflect what you see in generation II. Circle the mode of transmission. Note: Observe the whole pedigree. I Circle the mode of transmission 1 III 6 genotype (circle one): AA Created by Dr. Susan A. Holechek for BIO 340 (2023) 2 1 2 3 4 a) Autosomal recessive 11 x 12 9 XªXa 2 3 5 6 Ở хаха *4 7 b) Autosomal dominant 11x12 8 Aa *Unaffected/No carrier-Normal AaAa15 1 point What is the most likely mode of inheritance of the disease depicted in the following pedigree? ||| IV 1 autosomal dominant autosomal recessive 2 N 1 2 2 3 3 4 3 4 5 --DE. D. A. B. 11. C. Huntington's disease is a degenerative disease of the nervous system that strikes in middle age. The allele that causes the disease (H) is dominant to the allele that results in the normal condition (h). Answer the following questions about the inheritance of this disease. What is the genotype of a man who is normal but whose father had Huntington's disease? What is the genotype of a woman who has Huntington's disease if both of her parents had Huntington's disease? If a man who is heterozygous for Huntington's disease marries a woman who is normal, what would you expect for the genotypes and phenotypes of their children? If a normal man marries a woman who is homozygous for Huntington's disease, what do you expect for the genotypes and phenotypes of their children? Since Huntington's disease is caused by a dominant allele, does this mean it's also the most common allele in the population? F. Since Huntington's disease is caused by a dominant allele, does this mean…
- II. Write TRUE if the statement is correct and FALSE if otherwise. -7. A temale parent possessing an X-linked dominant mutation is considered a carrier and will not manifest clinical symptoms of the disorder. _8. Y-linked traits are passed from the father to son, without the occurrence of genetic recombination. 9. Somatic mosaicism results to abnormalities based on the amount and distribution of normal cells while gonadal mosaicism affects the germline tissues leading to a new dominant mutation. 10. A test cross is done to determine which allele is dominant and which is recessive.Match the following terms with their correct definition. A type of inheritance in which there is an earlier age of onset and a more severe phenotype in each successive generation. An effect in which the genotype of the mother determines the phenotype of the offspring. 1. Genetic anticipation 2. Position effect A type of inheritance were multiple genes contribute to the same phenotype. 3. Maternal effect 4. Pleiotropy A type of inheritance where one gene affects many different phenotypes. 5. Multigene (polygenic) inheritange An effect on gene expression from its location in an area of heterochromatin or euchromatin packaging.1. Study the given alleles. Write the correct phenotype for each genotype. X – normal Gen otype xC - Color-blind Phenotype XX XY XXC xCY 2. Study the given alleles. Write the correct genotype for each phenotype. xH - Hemophiliac Phenotype X- normal Gen otype Hemophiliac female Hemophiliac male Normal female carrier of the gene Normal male Normal female 28 3. Determine the genotype and phenotype of the offspring. A color-blind mother (XCx) married a normal sighted (XY) father. Genotype: Phenotype: Genotype: Phenotype: Genotype: Genotype: Phenotype: Phenotype: a. There are b. There are c. There are d. There are % normal sons. % normal daughters. % color-blind sons. % color-blind daughters. % normal female, carrier of the disorder. or or or or e. There are or