6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite

6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter9: Alkynes: An Introduction To Organic Synthesis

Section9.SE: Something Extra

Problem 28AP

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