MM IV-1 IV-2 III-1 III-2 III-3 A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual II-2?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
icon
Concept explainers
Question
MM
IV-1
IV-2
III-1
III-2
III-3
A) Using all available information, what is the correct inheritance pattern of this trait?
Why?
B) Draw the pattern that would result for DNA amplification of individual I-2 in the
empty lane of the gel.
C) What is the probability if individual IV-1 mates with an affected male that their
offspring will be an affected
female?
D) What is the genotype of individual II-2?
Transcribed Image Text:MM IV-1 IV-2 III-1 III-2 III-3 A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual II-2?
Examine the pedigree of the McGraw family shown below. Certain individuals in this
family are affected by a brain condition that makes them more susceptible to vertigo.
As a genetic counselor, you interview the family and draw DNA samples. You
discover that the condition is caused by a mutation that changes the sequence
5'GCATTC3' to 5'GAATTC3' introducing an EcoRI cut site. You decide to amplify a
1200bp fragment from the DNA that spans this mutation and then digest it with
EcoRI. You run the results on a gel next to a marker that shows bands at 2000bp,
1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree are
identified on the gel.
Transcribed Image Text:Examine the pedigree of the McGraw family shown below. Certain individuals in this family are affected by a brain condition that makes them more susceptible to vertigo. As a genetic counselor, you interview the family and draw DNA samples. You discover that the condition is caused by a mutation that changes the sequence 5'GCATTC3' to 5'GAATTC3' introducing an EcoRI cut site. You decide to amplify a 1200bp fragment from the DNA that spans this mutation and then digest it with EcoRI. You run the results on a gel next to a marker that shows bands at 2000bp, 1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree are identified on the gel.
Expert Solution
steps

Step by step

Solved in 3 steps with 1 images

Blurred answer
Knowledge Booster
DNA and RNA
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON