(Lecture 13 Study Guide, Question #10) Genetic traits on the X-chromosome are called X-linked. Some X-linked conditions are referred to as X-linked dominant, such as Fragile X Syndrome. Consider the following genetic cross: A father with Fragile X Syndrome and a mother with normal phenotype. Perform a Punnett Square. Select the possible genotypes of their offspring below. xfY xFxf xFY
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- My Question is what is the probability their first child will have hemophilia and drawn pedigrees for family members with genotypes. My explantion so far: A man has both X and Y chromosomes as sex chromosomes in his body. Here, though the brother of the man is hemophiliac, a man can’t be a carrier of hemophilia. So, it can be said that his chromosome is “XnY”.Here, the “n” stands for “normal”.Though the paternal uncle is hemophiliac, a man cannot be a carrier of hemophilia, his niece will not be a career. So it can be said that the woman is also not a carrier and has the “XnX” chromosome.So, as the mother is not a carrier, their first child does not have a chance of having hemophilia. This can be determined as it is known that there is no hidden carrier of hemophilia in the family.The allele for color-blindness is carried on the X chromosome. Making color blindness (a recessive trait) an X - linked trait. A colorblind make and a carrier female for color blindness. (But is not colorblind herself) have a child. Show your work! A) what is the % chance that their son will be color blind? B) what is the % chance that their daughter will be color blind?Match the term with the correct definition or example Question 27 options: Product of a cross between true breeding plants that make yellow peas and true breeding plants that make green peas. A description of the alleles present in an individual at one or more loci. Example: MM or Mm or mm. Example: 11q1. 4-q2. 1", meaning it is on the long arm of chromosome 11, somewhere in the range from sub-band 4 of region 1 to sub-band 1 of region 2. Under a microscope, these look exactly the same. The centromere, banding, long arm, short arm, overall length, gene locations, and order of genes are exactly the same. However, nucleotide sequences in genes on the two chromosomes can differ. the unit of heredity, the sequence of nucleotides in the exon regions specifies the sequence of amino acids in a particular polypeptide Brown allele in eye color Red eye in fruit flies Ability to synthesize alcohol dehydrogenase…
- Answer the following questions given the pedigree below. Please assume that no other mutations are occurring, complete penetrance, and that the individual marked with an asterisk (*) doesn’t carry the allele causing the affected phenotype. Q4) Assuming II-2 and II-3 want to have another child. what are all the possible genotypes, and what is the percentage that their child will be affected?Use keyboard only to enter your answer below. ALL WORKING MUST BE SHOWN Problem 1) mutation in a gene on chromosome 15 that codes for an enzyme. The disease is an inherited autosomal recessive condition which is Tay-Sachs disease is caused by loss of function found amongst Ashkenazi Jews of Central European origin. In this population, 3 in 5,200 children are born with the disease. What proportion of the population are carriers (heterozygotes) for this disease?A couple contemplating a pregnancy are in today for an appointment at a genetic counselling clinic to identify and interpret their risk of an inherited disorder. The nurse explains during teaching that all the following are characteristic features of fragile X chromosome of a 3-year-old male child EXCEPT: a. Macroorchidism b. Autistic behavior c. Intellectual disability d. Characteristic facial features e. Hyperextensible finger joints
- In this part, you will work out on X-linked traits. Remember that males have only one X chromosome and females have two. For X-linked recessive, use the following designations: XA= normal Xa= the trait (a genetic disease or abnormality) For X-linked dominant, use the following designations: XA= the trait (a genetic disease or abnormality) Xa= normal Determine if the pedigrees below can be for a trait that is X-linked recessive. Write the genotype next to the symbol for each person in the pedigree below. A. Is it possible that this pedigree is for an X-linked recessive trait? B. What can you conclude about the children of mothers affected with an X-linked recessive characteristic? C. What can you conclude about the father of an affected female?A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?Congenital hypertrichosis (CH) is a very rare X-linked dominant inherited condition. CH is characterized by the growth of dark hair over the body. CH is so rare, only 50 cases have been identified since the Middle Ages. The incidence of this condition is considerably higher in a small Mexican village (from which the partial pedigree below is derived) than the rest of the human population. I II III Use the following information to answer the two questions. IV D II-4 8 9 IV-6 0=10~ 11 1. Using appropriate nomenclature, identify the genotypes for the following 2 individuals: 12 13 your response must include an appropriate legend/key to identify allele symbols. 2. Show how a Punnett square (using the allele symbols from the previous question) is used to determine the probability in percent of individuals III-11 and III-12 next offspring has CH?
- Question: The disorder: Red-Green color blindness Explain the mode of inheritance of the disorder (recessive, dominant, x-linked, etc.) . Can a person be a carrier of this disorder? • Describe the probability of having a child with the disorder -- give a specific scenario (ex. both parents are heterozygous for the trait) • Describe the symptoms associated with this disorder Explain the prognosis of a person born with this disorderAnswer the following: 1. What sex chromosome combination does a female have? 2. What sex chromosome combination does a male have?, 3. How many chromosomes are in normal human cells? Use the internet to define karyotype: Karyotype - The pictures below show normal (all 46 non-damaged chromosomes) }} 88 31 10 71 al X X X X 46,XX id ZWK99010 KEY 28 20 38 21 AC 11 RR 16 8.8 22 10 17 X 11 Female Karyotype (2 X chromosomes) Male Karyotype (XY chromosomes) Why would scientists use karyotypes? Scientists use karyotypes to diagnose genetic disorders. A karyotype can show if there are extra, missing, or structurally damaged chromosomes. Predict: What could cause someone to have missing or damaged chromosomes?Assuming no other abnormalities, classify each of the following human sex chromosome complements as to whether or not individuals with that complement will be morphologically male or female. Three human sex chromosome complements will be classified as male and three will be classified as female. XXY XYY XXX XO XY XX