In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth {d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COL1A1) gene are present in an individual's chromosome 17. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest OI. What is the genotype of... a.1. the man's father? a.2. the man's mother? a. b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing the cross.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...
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In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene
in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal
teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis
imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the
recessive allele (c) for collagen type I (COLIA1) gene are present in an individual's chromosome 17.
2.
A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to
a father who has discolored teeth and a mother who has normal teeth. Both the man's father and
mother do not manifest Oi. What is the genotype of...
a.1. the man's father?
a.2. the man's mother?
a.
b.
If this man in (a) would marry, what should be the genotype of his wife in order that none of their
future children will manifest any of the conditions? Support your answer by showing the cross.
Transcribed Image Text:In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COLIA1) gene are present in an individual's chromosome 17. 2. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Oi. What is the genotype of... a.1. the man's father? a.2. the man's mother? a. b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing the cross.
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