If removal of the pancreas results in a variety of metabolic disturbances that ultimately lead to death, describe the most significant biochemical and physiological changes that would occur due to loss of endocrine function of the pancreas.
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If removal of the pancreas results in a variety of
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- Discuss how diabetic ketoacidosis (DKA) occurs and its clinical manifestations. In your response be sure to address the following points (i) the three events that characterize DKA; (ii) the underlying molecular causes of each of the three events; (iii) the clinical manifestations and treatments of DKA.Which of the following best describes the role of the hexosamine pathway in the pathogenesis of the chronic complications of diabetes mellitus? Question 79 options: a) It involves irreversible binding of glucose to proteins, lipids and nucleic acids which damages components of the microcirculation leading to retinopathy, etc. b) It promotes the O-linked glycosylation of proteins and transcription factors, resulting in altered gene expression contributing to insulin resistance & cardiovascular complications c) It promotes the synthesis of DAG which increases pro-inflammatory gene expression and endothelial ET-1 production resulting in blood flow abnormalities d) It leads to intracellular accumulation of osmotically active sorbitol and fructose which damages Schwann cells, erythrocytes and the lens of the eyeExplain the concept of autodigestion and describe twospecific effects of this process in the pancreas.
- The pathophysiology of chronic diabetic complications is related to which process? Question 65 options: a) Oxidative stress and ROS have a limited role in the pathophysiology of diabetes mellitus b) Sorbitol and fructose are products of the polyol pathway that accumulate and reduce intracellular osmotic pressure causing cellular injury c) AGEs are formed by the irreversible binding of glucose to proteins, lipids and nucleic acids d) The hexosamine pathway causes pathologic changes in gene expression associated with increased insulin activity and improved cardiovascular healthDescribe the negative feedback control of blood glucose levels, and explain the roles of insulin and glucagon in regulating blood glucose levels. ANSWER SHOULD INCLUDE: Explain the meaning of "negative feedback control', Name the 2 hormones involved and which part of pancreas produces each one Explain the stimulus for release of each hormone. Explain the response to hyperglycaemia (what happens to glucose? Explain the meaning of term such as facilitated diffusion, glycogenesis , gluconeogenesis) Explain how blood glucose returns to normal (homeostasis) Explain the response to hyperglycaemia (what happens to glucose? What happens in glyconeogenesis?) In which organs do these events occur? Explain how blood glucose level returns to normal (homeostasis)Hypothyroidism is a condition in which the thyroid gland fails to produce adequate amounts crucial hormones. In the early stages, persons suffering from this condition may be asymptomatic. However, chronic hypothyroidism may show signs of paleness. Please explain the physiological reasons for this symptomatology.
- Describe the precipitants of ketoacidosis in this diabetic patient. What is the cause of his altered mental status?The hormones insulin and glucagon play an important role in the regulation of plasma glucose. b) People with Type II diabetes mellitus can manage their condition (maintain adequate glycaemic control) through use of oral hypoglycaemic drugs. Provide a rationale for how two hypoglycaemic drugs, with different mechanisms of action, can both work to lower blood glucose levels in Type II diabetes.Congenital adrenal hyperplasia is a lifethreatening condition that results from a deficiency in the P450 enzyme steroid 21- hydroxylase. This enzyme catalyzes the first step in the conversion of progesterone into cortisol and aldosterone (Figures 26.28 and 26.29). A characteristic of congenital adrenal hyperplasia is an increase in sex hormone production. Explain why this is the case.
- Does insulin stimulate receptors in the liver? True or false. Explain.Name two hormones, four enzymes, and one buffer secreted by the pancreas, and state the function of each.Which of the following is true about the pathophysiology of hypoglycemia? Question 62 options: a) Glucagon decreases glycogenolysis and gluconeogenesis in the liver b) Autonomic symptoms are caused by increased levels of glucagon which then stimulates the hypothalamic-pituitary-adrenal axis c) Beta cells suppress insulin secretion at a plasma glucose level of 3 mmol/L d) Abrupt cessation of glucose delivery to the brain results in confusion, drowsiness, vision changes, and headache