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- . The human IGF2 gene is autosomal and maternallyimprinted. Copies of the gene received from themother are not expressed, but copies received fromthe father are expressed. You have found two allelesof this gene that encode two different forms of theIGF2 protein distinguishable by gel electrophoresis.One allele encodes a 60K (Kilodalton) blood protein;the other allele encodes a 50K blood protein. In ananalysis of blood proteins from a couple named Billand Joan, you find only the 60K protein in Joan’sblood and only the 50K protein in Bill’s blood. Youthen look at their children: Jill is producing only the50K protein, while Bill Jr. is producing only the 60Kprotein.a. With these data alone, what can you say about theIGF2 genotype of Bill Sr. and Joan?b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. Withthe accumulated data, what can you now say aboutthe genotypes of Joan and Bill Sr.?Tick all the essential steps to demonstrate a genetic linkage between a disease and a molecular marker in humans. identify the alleles of the genetic marker only for diseased individuals in the pedigree enumerate parental type individuals sequence the wild-type and mutant alleles to find the mutation no correct answer calculate a Lod score calculate the recombination frequency between the mutation and the molecular marker identify the alleles of the genetic marker for each individual in the pedigree pedigree analysis cloning the defective gene enumerate recombinant individualsTopic: Gene Locus Height in gryphons is determined by a single locus. You cross a two 9' tall gryphons and get 1/4 10'; 1/2 9' and 1/4 8' tall gryphons. If you across two 7' tall gryphons you get 1/4 8', 1/2 7'; 1/4 6' tall gryphons. pls kindly help to explanation: why In gryphons, alleles of the height lous are semidominant and form an allelic series. A.
- Please type your answer 1A. What is the molecular basis for genomic imprinting? B. How is the process of X-chromosome inactivation similar to genomic imprinting. C. How is the process of X-chromosome inactivation different from genomic imprinting. D. In mice, the Igf2 gene inherited from the mother is never expressed in her offspring? Explain. E. What genes are deleted in a female born with Angelman syndrome. Which parent transmitted the deletion to her?What is FISH? Briefly describe how it works How is FISH used to characterize chromosomal translocations associated with certain genetic disorders and specific types of cancers?EC4. In a test-cross of trihybrid drosophila the following phenotypes and number of offspring were found. Without doing any calculations, answer the following questions: +++ 669 abc 653 ++c 121 ab+ 139 +b+ 2280 a+c 2215 +bc 3 a++ 2 a) What were the genotypes of the parental strains? (fill in) b). What is the gene order?
- Preimplantation genetic testing for aneuploidy (PGT-A) is meant to identify and discard embryos with chromosome number abnormalities. However, it has not been proven to be valuable in human IVF. What do you think PGT-A is not working as expectedmapping three linked genes, the heterozygous AaBbCc was crossed to aabbcc individual the following phenotypes were obtained: ABC 4 abc 2 ABc 150 abC 141 aBc 18 AbC 20 Abc 30 aBC 35 A) What are the alleles found on each parental chromosome(genotypes of the parents)? B) How many double recombinants(cross over) were there? c) what is the linear arrangement of loci on the chromosome?Evidence [see P. G. Shiels, A. J. Kind, K. H. Campbell, et al. (1999),“Analysis of telomere lengths in cloned sheep,” Nature 399, 316–317] suggests that Dolly may have been genetically older than heractual age. As mammals age, the chromosomes in somatic cells tendto shorten from the telomeres. Therefore, older individuals haveshorter chromosomes in their somatic cells than do younger ones.When researchers analyzed the chromosomes in the somatic cells of Dolly when she was about 3 years old, the lengths of her chromosomeswere consistent with those of a sheep that was significantlyolder, say, 9–10 years old. (Note: As described in the chapter, thesheep that donated the somatic cell that produced Dolly was 6 yearsold, and her mammary cells had been grown in culture for severalcell doublings before one of the cells was fused with an oocyte.)A. Suggest an explanation why Dolly’s chromosomes seemedolder than they should have been.B. Let’s suppose that a female sheep (like Dolly), which…
- Attempt 2 Suppose a geneticist is using a three-point testeross to map three linked Drosophila recessive mutations called f, w, and b, where fis associated with abnormally fast movement, w is associated with wavy movement pattern, and b is associated with broad wings. The geneticist first crosses homozygous broad flies to homozygous fast, wavy flies. Next, he testerosses the Fi progeny to fast, wavy, and broad parents and obtains the results in the table. Fi testcross progeny phenotype Number broad 627 fast, wavy 627 wavy 231 fast, broad 207 fast 207 wavy, broad fast, wavy, broad 229 wild type Based on this data, select the order of the three genes. bfw O fb w OwfhLinkage Mapping Using Dihybrid Testcrosses in Fruit Flies In fruit flies, the normal honey-gray body-color (bl*) is dominant to black (bl), having normal red eyes (pu+) is dominant to purple (pu), and having normal wings (vg+) is dominant to vestigial (vg). The three genes are located close together on the same chromosome. Your task is to use data from three dihybrid testcrosses to (1) calculate recombination frequencies, (2) convert recombination frequencies into map distances, and (3) build a map of the chromosome interval covered by the three genes, indicating their order and distances between them. BLACK PURPLE DIHYBRID CROSS In the parental generation, you mate a pure-breeding wild-type female (bl+/blt;put/pu+) with a pure-breeding black, purple male (bl/bl;pu/pu) to produce an F1 generation that is all wild-type (bl+/bl;pu*/pu). Note that the F1 flies are all dihybrid. Next, you mate several F1 dihybrid females (bl+/bl;pu*/pu) with tester males, which are black, purple…Q. what would you predict to observe among the offspring of the following cross? A Drosophila line containing ey-GAL4 is crossed to a line containing UAS-GFP, actin-GAL80.
