Answered: heart failure is unable to climb a…

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Nursing

heart failure is unable to climb a flight of stairs without experiencing dyspnea.

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter25: Cardiovascular Drugs

Section: Chapter Questions

Problem 11CRQ

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Question

A 65-year old man with heart failure is unable to climb a flight of stairs without experiencing dyspnea. After several years of therapy with carvedilol, captopril and furosemide, the therapeutic plan probably needs to change now. You empirically add digoxin to improve cardiac muscle contractility. Within 4 week he has a marked improvement in his symptoms. Which of the following best describes the main cellular action of digoxin that accounts for its ability to improve his cardiovascular function?

Activates beta1-adrenergic receptors
Facilitates GTP binding to specific proteins
Increases mitochondrial calcium (Ca++) release
Inhibits sarcolemmal Na/K-ATP-ase

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