have generated 5 different cancer cell lines in your laboratory. In cancer cell line A there is a deletion of gene A  In cancer cell line B, the promoter for gene B is over-methylated In cancer cell line C, there is a nonsense mutation near the start codon of gene C In cancer cell line D, there is a duplication of gene D  In cancer cell line E, a translocation puts gene E close to an active promoter Each of the genes above

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter16: Regulation Of Gene Expression
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You have generated 5 different cancer cell lines in your laboratory.

    • In cancer cell line A there is a deletion of gene A 
    • In cancer cell line B, the promoter for gene B is over-methylated
    • In cancer cell line C, there is a nonsense mutation near the start codon of gene C
    • In cancer cell line D, there is a duplication of gene D 
    • In cancer cell line E, a translocation puts gene E close to an active promoter

Each of the genes above is implicated in cancer.  What is most likely, given the information? 

  1. Gene A is likely to be a:       Proto-oncogene/ Tumor Suppressor/ Neither
  2. Gene B is likely to be a:       Proto-oncogene/ Tumor Suppressor/ Neither
  3. Gene C is likely to be a:       Proto-oncogene/ Tumor Suppressor/ Neither
  4. Gene D is likely to be a:        Proto-oncogene/ Tumor Suppressor/ Neither
  5. Gene E is likely to be a:        Proto-oncogene/ Tumor Suppressor/ Neither
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