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- Describe the chromosomal alterations and phenotype of cri du chat syndrome and Prader-Willi syndrome.Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?Chands syndrome is an autosomal recessive condition characterized by very curly hair, underdeveloped nails, and abnormally shaped eyelids. In the pedigree below: Which individuals must be carriers (heterozygotes)? -----
- Ectrodactyly is a rare condition in which the fingers are absent, and the hand is split. It is usually inherited as an autosomal dominant trait. What do the double horizontal lines mean between III-1 and III-4? Is the pedigree below consistent with autosomal dominant inheritance?Refer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddCould the pedigree in Figure 2-31 be explained as an autosomal dominant disorder? Explain.
- 58 A family has two children with an undiagnosed, very rare neurodevelopmental condition illustrated in the pedigree below. Neither parent is affected and there is no family history of this disorder. The following two questions relate to this pedigree. What is the most likely mode of inheritance for this condition? Select one alternative: Dominant O It is not inherited Recessive X-linked recessiveFor the following problems, please choose from the following modes of inheritance: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive 8080 50 OTO ㅁㅇㅇㅁ I. What is the most likely mode of inheritance portrayed in the pedigree above?The following pedigree illustrates the inheritance of Duchenne Muscular Dystrophy, a condition characterized by progressive weakness and degeneration of skeletal muscles due to absence of dystrophin. 2.
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).Is this pedigree dominant or recessive. Which best defines this pedigree Autosomal or sex-linked?6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 is