Given the following data for Lisinopril, pick the best answer based on Lipinski rules of five:isinoprilOHH-NNHOHMW = 405.5 g/molLog P = -1.01Ol expect bad oral bioavailability because it broke all rules.Ol expect good oral bioavailability because it followed 3 rules.Ol expect good oral bioavailability because it followed all rulesOl expect good oral bioavailability because it broke 1 ruleOl expect bad oral bioavailability because it broke 2 rules

Lipinski rules of five: The properties of the oral drug are, Permeable or poor absorption Log P…

Answered: Given the following data for…

Given the following data for Lisinopril, pick the best answer based on Lipinski rules of five: isinopril HO- NH MW = 405.5 g/mol Log P = -1.01

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter19: Carboxylic Anhydrides, Esters, And Amides

Section: Chapter Questions

Problem 19.44P

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Concept explainers

Organometallic compounds of d-block elements

The transition metals can form complexes since they have vacant d orbitals. They are also termed Coordination compounds. The organometallic compounds of the transition metals could be used as catalysts as well as reagents. For example, organocadmium, organozinc, organocopper, Grignard are used as the reagents for several reactions. Most of the complexes of organo transition metals are used as catalysts for many organic transformation reactions.

Question

Given the following data for Lisinopril, pick the best answer based on Lipinski rules of five:
isinopril
OH
H-N
NH
OH
MW = 405.5 g/mol
Log P = -1.01
Ol expect bad oral bioavailability because it broke all rules.
Ol expect good oral bioavailability because it followed 3 rules.
Ol expect good oral bioavailability because it followed all rules
Ol expect good oral bioavailability because it broke 1 rule
Ol expect bad oral bioavailability because it broke 2 rules

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