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Folks will say that you share 25% of your DNA with your maternal grandmother. Is that accurate? Why or why not?
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- A wealthy elderly couple die together in an accident. Soon, a man shows up to claim their fortune, saying that he is their only son who ran away from home as a boy. Other relatives dispute his claim. Hospital records show that the deceased couple were type AB and0 respectively. The claimant to the fortune was type O. Could he be their son? Explain your answer. Two parents think their baby was switched at the hospital. It's 1968, so DNA fingerprinting technology does not exist yet. The mother has blood type A, the father has blood type AB, and the baby has blood type "B." 66 Mother's genotype(s): Draw a Punnett square showing all possible genotypes for children produced by this couple Father's genotype(s): Baby's genotype(s): What is the probability that the baby was switched?Which members of the pedigree could have been carriers, and which might have been the source of the mutation?Which of the following individuals would you expect to share 25% of their DNA with you? Select all correct answers. Your aunt or uncle Your child Your first cousin Your grandparent Your parent Your sibling
- What do you mean by holandric genes?Is the DNA of our father identical with the DNA in our mother?A couple enters your genetic counseling clinic for some family planning advice. The woman’s father was color blind, but her own vision is normal. The man has no family history of color blindness. Neither the man nor woman have any known history of hemophilia, but their first child (a boy) has hemophilia. They ask you to calculate the chance that their nextchild will be affected by one or both conditions. You remember from your genetics training that these are both X-linked recessive conditions and that they are closely linked: in fact, their genetic loci are separated by only 10cM! During the interview with this couple, you draw the following pedigree to represent their information. Given what you know, determine for this couple what chance they have of each of the following (in the table).
- The Hemoglobin gene has two very common alleles: HbS and HbA. Bob’s professor asks him to draw the chromosomes for an individual that is HbSHbA and label the alleles. Bob draws this (below). Explain why Bob is wrong and then draw it correctly. FOXP2 is a gene in humans; humans that have mutated copies of FOXP2 often have trouble speaking. It is on Chromosome 7, which is about 160 million base pairs long. FOXP2 is at position 115 million base pairs. Which of the drawings below appropriately diagrams the location of FOXP2? Why?An important application of DNA fingerprinting is relationship testing. Persons who are related genetically have some bands or peaks in common. The number they share depends on the closeness of their genetic relationship. For example, an offspring is expected to receive half of his or her minisatellites from one parent and the rest from the other. The diagram shown here schematically illustrates traditional DNA fingerprints of an offspring, mother, and two potential fathers. In paternity testing, the offspring’s DNA fingerprint is first compared with that of the mother. The bands that the offspring have in common with the mother are depicted in purple. The bands that are not similar between the offspring and the mother must have been inherited from the father. These bands are depicted in red. Which male could be the father?A couple is planning a family, but since each has a brother having the sickle-cell disorder, they are worried that their kids might develop the disorder too. Neither of them nor their respective parents have the disorder. Which of the following will be your smartest advice as a genetic counsellor? One of four of their children can be expected to have sickle cell. It is possible that none of their kids will have the disorder, but tests should be carried out on both of them to confirm. All of their children will have sickle-cell disorder. There is no chance of any of their kids having sickle cell.
- You've been having trouble sleeping because of your obsession with understanding the Rh factor (+ positive or - negative) in blood typing. Your blood type is O-. You know both of your parents phenotypes so you decide to visit a famous genetic counselor, Dr. Jean Etix. After she bills you $300, she tells you to take your parents' genotypes and "stick them in a punnet square!" Your Dad is B- and your Mom is A+. What are their possible genotypic combinations? O Pi++ and^i +- Oi+- and Ai +- O IPi+- and IAA+ +- and Ai+- O Pi -- and IAi +-The pedigree pictured is of an extended family where a large percentage of family members develop colon cancer at an early age. In this family, individuals either get colon cancer before the age of 16, or they don’t get it at all. a) Based on the information you have been given, what evidence, if any, suggests an inherited contribution to the development of this disease? b) You take a medical history of all 33 people in the pedigree and discover that a large percentage drink a special coffee on a daily basis, while others do not. The individuals who do not drink coffee are I-1, II-2, II-4, II-9, III-7, III-13, IV-1, and IV-3. Could drinking this special coffee play a role in colon cancer? Explain.Imagine you've been offered a deal from a genomics company. You can get a free genome sequence – an analysis of all your DNA that includes a report of your ancestry, traits and a medical profile. The medical profile tells you about diseases for which you have a low risk of getting, and also those you have a high risk of getting. Are you interested? Why or why not?