Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter42: The Immune System
Section: Chapter Questions
Problem 19RQ: A potential cause of acquired autoimmunity is ___________ . tissue hypersensitivity molecular...
Related questions
Question
Please help explain
Transcribed Image Text:Fig. 1: Vpr counteracts LAPTM5 to promote
HIV-1 infection in macrophages.
a
10ng HIV-1
100ng HIV-1
ADB
shCtrl
SHLAP-1
shCtrl
SHLAP-1
ADB Vpr-
20
25
80
80
20-
15
60
60-
15-
10
40-
40
Donor-1
10-
20
20
5-
0-
36 9 12 15 18 369 12 15 18
3 6 9 12 15 18
3 6 9 12 15 18
80
20
50
15
40-
60-
30
10
40
20-
Donor-2
20-
10
3 6 9 12 15 18
369 12 15 18
3 6 9 12 15 18
3 69 12 15 18
15-
25-
80
80
20
60-
10-
60
15
40
20-
401
Donor-3
10-
5-
20
36 9 12 15 18
369 12 15 18
369 12 15 18
3 69 12 15 18
Day
b
shCtrl
SHLAP-1
Bal.
+ Bal. Vpr-
shCtrl
SHLAP-1
• 89.6
+ 89.6 Vpr-
20
15
15
10
Donor-4
20
Donor-6
10
369 12 15 18
369 12 15 18
69 12 15 18
369 12 15 18
25
20
30
30
20
20-
Donor-5
Donor-7
10-
10
0-
36 9 12 15 16
Day
369 12 15 18
Day
369 12 15 18
Day
3 69 12 15 18
Day
d
SHLAP-3'-UTR
e
SHLAP-UTR
+ Vector
shCtrl
SHLAP-UTR
+ LAPTM5 Vector
40
50
50
AD8
+ AD8 Vpr-
40-
40-
30-
30
30-
37-
20-
LAPTM5
20
Donor-8
10-
GAPDH
37-
10
10 -
MDM
3 6 9 12 15 18
3 6 9 12 15 18
3 6 9 12 15 18
Day
p24 (ng/mL)
p24 (ng/mL)
shCtrl
SHLAP-UTR
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 3 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax