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Female patient whose is a 13-year-old, was admitted to the hospital with complaints of progressive weakness and shortness of breath with minimal physical effort. She has experienced recurrent fevers reaching 38.8°C. Physical examination reveals a well developed teenage with good nutritional status and in no acute distress. There is no lymphadenopathy or organomegaly. Many petechial hemorrhages cover her chest and legs. Several bruises are found on her legs and thighs. Laboratory tests were ordered upon admission. The laboratory tests result were as the following: RBC 2.24 X102 /1 Hb PCV Plt WBC 1.2 X109/1 Differential 71 g/ 24% 8.0 X10/1 Segmented Neutrophils Lymphocytes Monocytes Reticulocyte count 2% 94% 4% 0.7% She was referred to a hematologist who ordered a bone marrow examination. Bone marrow biopsy showed a markedly hypocellular marrow with very few hematopoietic cells and there were no malignant cells present. 1- Connect these clinical symptoms with her laboratory-screening test results? 2-Select laboratory tests appropriate for screening for aplastic anemia? 3- Justify the selection of laboratory screening tests based on patient's clinical signs and symptoms?

Female patient whose is a 13-year-old, was admitted to the hospital with complaints of progressive weakness and shortness of breath with minimal physical effort. She has experienced recurrent fevers reaching 38.8°C. Physical examination reveals a well developed teenage with good nutritional status and in no acute distress. There is no lymphadenopathy or organomegaly. Many petechial hemorrhages cover her chest and legs. Several bruises are found on her legs and thighs. Laboratory tests were ordered upon admission. The laboratory tests result were as the following: RBC 2.24 X102 /1 Hb PCV Plt WBC 1.2 X109/1 Differential 71 g/ 24% 8.0 X10/1 Segmented Neutrophils Lymphocytes Monocytes Reticulocyte count 2% 94% 4% 0.7% She was referred to a hematologist who ordered a bone marrow examination. Bone marrow biopsy showed a markedly hypocellular marrow with very few hematopoietic cells and there were no malignant cells present. 1- Connect these clinical symptoms with her laboratory-screening test results? 2-Select laboratory tests appropriate for screening for aplastic anemia? 3- Justify the selection of laboratory screening tests based on patient's clinical signs and symptoms?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Female patient whose is a 13-year-old, was admitted to the hospital with complaints of progressive weakness and shortness of breath with minimal physical effort. She has experienced recurrent fevers reaching 38.8°C. Physical examination reveals a well developed teenage with good nutritional status and in no acute distress. There is no lymphadenopathy or organomegaly. Many petechial hemorrhages cover her chest and legs. Several bruises are found on her legs and thighs. Laboratory tests were ordered upon admission. The laboratory tests result were as the following: RBC 2.24 X1012 /1 Hb 71 g/l 24% 8.0 X10/1 PCV Plt WBC 1.2 X109/1 Differential Segmented Neutrophils Lymphocytes Monocytes Reticulocyte count 2% 94% 4% 0.7% She was referred to a hematologist who ordered a bone marrow examination. Bone marrow biopsy showed a markedly hypocellular marrow with very few hematopoietic cells and there were no malignant cells present. 1- Connect these clinical symptoms with her laboratory-screening test results? 2-Select laboratory tests appropriate for screening for aplastic anemia? 3- Justify the selection of laboratory screening tests based on patient's clinical signs and symptoms? 4- If aplastic anemia is present, would you expect her to have an idiopathic or secondary form? Explain your answer. 5- What information of this patient's history may be associated with the occurrence of aplastic anemia? 6- Is it likely that she has a congenital form of aplastic anemia? Explain your answer. 7- Evaluate each of the patient's laboratory results by comparing them to reference ranges? 8- Classify the morphologic type of anemia. 9- Predict a treatment for this patient. 10- What are other diseases may expected in this patient? What are the tests you could differentiate the aplastic anemia form these diseases?
Transcribed Image Text:Female patient whose is a 13-year-old, was admitted to the hospital with complaints of progressive weakness and shortness of breath with minimal physical effort. She has experienced recurrent fevers reaching 38.8°C. Physical examination reveals a well developed teenage with good nutritional status and in no acute distress. There is no lymphadenopathy or organomegaly. Many petechial hemorrhages cover her chest and legs. Several bruises are found on her legs and thighs. Laboratory tests were ordered upon admission. The laboratory tests result were as the following: RBC 2.24 X1012 /1 Hb 71 g/l 24% 8.0 X10/1 PCV Plt WBC 1.2 X109/1 Differential Segmented Neutrophils Lymphocytes Monocytes Reticulocyte count 2% 94% 4% 0.7% She was referred to a hematologist who ordered a bone marrow examination. Bone marrow biopsy showed a markedly hypocellular marrow with very few hematopoietic cells and there were no malignant cells present. 1- Connect these clinical symptoms with her laboratory-screening test results? 2-Select laboratory tests appropriate for screening for aplastic anemia? 3- Justify the selection of laboratory screening tests based on patient's clinical signs and symptoms? 4- If aplastic anemia is present, would you expect her to have an idiopathic or secondary form? Explain your answer. 5- What information of this patient's history may be associated with the occurrence of aplastic anemia? 6- Is it likely that she has a congenital form of aplastic anemia? Explain your answer. 7- Evaluate each of the patient's laboratory results by comparing them to reference ranges? 8- Classify the morphologic type of anemia. 9- Predict a treatment for this patient. 10- What are other diseases may expected in this patient? What are the tests you could differentiate the aplastic anemia form these diseases?
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