Fast forward 10 years, and you are working as a dermatologist specializing on hands. You notice almost all your patients who have nail patella syndrome (N: disease; n: wild-type) are also O blood type (genotype at the ABO gene: OO). Seems like a weird coincidence, until you remember that the genes causing these two traits are linked and 10 cM apart. If someone who is NBnO has children with someone who is NBnO, what is the probability they would have a kid without nail patella syndrome who is also B-blood type (genotype: BB).

Fast forward 10 years, and you are working as a dermatologist specializing on hands. You notice almost all your patients who have nail patella syndrome (N: disease; n: wild-type) are also O blood type (genotype at the ABO gene: OO). Seems like a weird coincidence, until you remember that the genes causing these two traits are linked and 10 cM apart. If someone who is NBnO has children with someone who is NBnO, what is the probability they would have a kid without nail patella syndrome who is also B-blood type (genotype: BB).

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 19QP: Analysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal,...

See similar textbooks

Similar questions

Retinoblastoma: The Hits Just Keep Coming Part I – White Spots Questions Whitt noted leukocoria and strabismus. Define these terms. Based on what you know so far, create a pedigree that depicts the prevalence of cancer in this family. Indicate Kay as the proband. Consider the pedigree that you just drew. What mode of inheritance seems most likely? Justify your prediction. What is the difference between a sporadic cancer and an inherited (or familial) cancer? Which is most common? Based on the pedigree you drew; do you think that the cancer in this family tree is sporadic or inherited? Why? Briefly, describe the fundamental problem that distinguishes a cancer cell from a non-cancerous cell.
Let us practice it again! Analyze the pedigree below to answer the questions that follow. Huntington's disease a disorder in which nerve cells waste away, or disintegrate, is passed down through families. certain parts of the brain Huntington's diseate llustration ereated in htps://pregenygenetion.com/ 1. What members of the family above are affected with the Huntington's disease? 2. Tnere are no carriers ior Huntungton's disease you either have it or you do not. Is Huntington's disease caused-by a dominant or recessive trait? 3. Identify the genotypes of the following individuals using the pedigree above. (homozygous dominant, homozygous recessive, heterozygous). I- 1 II -1: II -3: III - 4 : 4. How many children did individuals I-1 and I-2 have? 5. How many girls did II-1 and II-2 have? How many have Huntington's Disease? 6. How are individuals III-2 and II-4 related? I-2 and III-5?
How many (%) of their daughters will have hemophilia? 8. Beta thalassemia is a blood disorder caused by a mutation in the HBB gene on chromosome 11 which codes for the beta subunit of the hemoglobin protein. This changes the shape and functioning of the protein and causes it to misshapen and unable to carry oxygen efficiently. The disorder is recessive. Normal Beta thalassemia If two parents are carriers for the disorder, what percentage of their children will have Beta Thalassemia? How many (%) of their children will have beta thalassemia? Are males and females affected equally? How do you know?
Pedigree 3: What is the most likely mode of inheritance of this disease given its pattern on the pedigree? Autosomal Dominant O Autosomal Recessive O X-Linked Dominant O X-Linked Recessive
dominant-therefore someone with AB genotype has AB phenotype. You can see both because they are codominant) i) What are the possible genotypes for someone with A blood type? ii) What about B blood type? iii) Let's assume that an person by the name of Dustin Beilber (this name sounds really familiar for some reason) is taken to trial in a paternity suit by a woman claiming that he is the father of her child. He claims he is not the father. At the trial, an expert witness reveals the blood types of all three: Dustin's blood type – B Mother's blood type – A Child's blood type – O Based on these data, is it possible that Dustin is the father of this child? (To put this in terms of the scientific method, you are trying to disprove the hypothesis that Dustin is the father). If you can't disprove this, it doesn't mean that he is the father, it simply means that you cannot reject the hypothesis). Explain your answer.
The ff. mothers, (A) through (E) with given phenotypes, each produced one child whose phenotype is described. For each child, select as the father ONE of the five males whose genotypes are given. Genotype of male (1) IA i MN rr XAY (2) IB i MN RR XAY (3) ii NN rr XAY (4) ii MM rr XaY (5) IAIA MN RR XaY Give possible genotypes of all the mothers and children: Mother Maternal Phenotype Phenotype of child Possible father (write number only) A Type A, M, Rh+, normal color vision Type O, M, Rh+ , normal color vision, male B Type B, N, Rh-, colorblind Type O, N, Rh-, colorblind male C Type O, M, Rh-, normal color vision Type A, MN, Rh+, colorblind, female D Type A, N, Rh+, normal color vision Type AB, MN, Rh+, normal color vision, female E Type AB, MN, Rh- , normal color vision Type AB, M, Rh-, colorblind, male
Retinoblastoma: The Hits Just Keep Coming Part IV – Time to Reconvene Question Since Julie is indeed a carrier of the mutated RB1 allele and Chris is homozygous for the wild-type allele, what is the likelihood that their next child will inherit Julie’s RB1 mutation? Part V – A Different Kind of Hit Question Chris does not have an RB1 mutation, and is therefore homozygous wild-type. Julie is heterozygous for the mutation. However, Kay has inherited a different RB1 mutation than the one her mother carries. Therefore, Kay did not receive her mother’s mutant allele. Assuming that Chris really is the father, what other explanation might there be for how she got a germline mutation?
4. What mode of inheritance is shown in the pedigree chart on the left? Justify your answer. 5. Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.
Pedigree 3: NOTE: the asterisk (*) indicates that the individual does not have any disease-related alleles. A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B State the genotypes of individuals #1 - #4. C What is the probability of individual A being affected (show the disease)? What is the probability of individual B being affected? Pedigree 4:
Pedigree 2: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B State the genotypes of individuals # 1 #4. C If individual #3 has another daughter with the same partner, what is the probability that this daughter will be affected (show the disease)?
Biology = genetics please do Challenge problem 3 Now, figure out the complementation groups. This shows how many genes are involved in this pathway. Some of the mutant classes in the previous problem must contain more than one complementation group (gene) For example class 2 is defined by mutants 1,3,4,6, and 7. These mutants may, or may not, all be in the same gene. Complementation testing will help you know if they are, or are not, in the same gene. So there are actually additional steps between some of the letters. For example, maybe instead of XàY, it is really X->F->G->Y.
A reciprocal translocation between chromosomes9 and __ contributes to chronic myelogenous leukemia.