Explain the use of plans and their importance in assessing the quality of pharmaceutical products. Provide a step-by-step design of a sampling plan based on a normal inspection for a 75,000 tablets with an AQL of 0.12% using the attached table (at the end of exam paper).
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Explain the use of plans and their importance in assessing the quality of pharmaceutical products. Provide a step-by-step design of a sampling plan based on a normal inspection for a 75,000 tablets with an AQL of 0.12% using the attached table (at the end of exam paper).
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- Write a step-by-step procedure for this serial dilution. The stock concentration of the blue dye standard is 1.00 mg/mL. Serial dilution series from the stock standard with the following final concentrations: 500 ug/mL, 250 ug/mL, 125 ug/mL, 62.5 ug/mL. and a blank that is 0ug/mlWhat is calibration and why is it essential in relation to food analysis? Provide examples.Table of chemicals and reagents with their physicochemical properties (name, molecular formula, molecular weight, pKa, melting point, boiling point, etc.) Write a short outline or a flow diagram of the procedure List and safety issues Read and understand the MSDS information for each chemical used in this practical Experimental procedure Please do not scratch the clear sides of the UV cuvettes as this will invalidate your results. Part 1: Preparation of a calibration curve A calibration curve should be constructed using at least five concentrations of the pure paracetamol standard supplied in the range 3-15 ug/mL as follows: Weigh about 150 mg of paracetamol accurately and transfer to a 200 mL volumetric flask. Add 50 mL of o.1 M NaOH and dilute to about 100 mL with deionised water (DI). Shake and make up to volume with DI water. Dilute 10 mL of the resulting solution to 100 mL (volumetric flask) with DI water (= stock solution). Prepare standard solutions containing 3, 6, 9, 12 and 15…
- 1. A student performed this experiment and obtained the following concentration values: 0.02813 M, 0.02802, and 0.02788 M a. what is the mean concentration? b. what is the standard deviation of these results? 3. how would the following errors affect the concentration of Cl- obtained in question 2b? give your reasoning in each case. a. the student read the molarity of AgNo3 as 0.02104M instead of 0.02014M b. the student was past the endpoint of titration when he took the final buret reading.What are the differences between systematic and random errors and how do they effect accuracy and precision? In what circumstances would you use standard addition (versus a normal calibration curve) to determine the amount of an analyte in a sample? A urine sample, containing analyte Z is analysed by the standard addition method where 5 mL of the original sample was mixed with increasing amounts of a Z standard and each solution diluted to a volume of 50 mL prior to analysis. A plot of the final concentration of the standard in each of the 50 mL samples (x axis) versus The measured signal from the analysis of each 50 mL sample (on y axis) produced a straight line with the general equation: y = 44.72x + 4.06 what was the final concentration of Z in the 50 mL standard addition sample? what was the initial concentration of Z in the original urine sample?Analytical chemistry is a particular field within the broader spectrum of the chemical sciences, in which many times the focus of analytical experiments is to develop new methods to analyze compounds, either structurally or by determining concentrations of compounds. One of the processes analytical chemists use to determine the exact concentration of a working solution is called standardization. In your own words, describe the differences between a primary, secondary, and tertiary standard, and describe the underlying concept behind the standardization process. Why is it done?
- How do you find the Moles and mass of acetic acid in vinegar How do you find the Molarity and Average molarity of acetic acid in vinegar How do you find the % by mass, the Average % mass, and Standard deviation of % of acetic acid in vinegarConsider the structure of testosterone to identify the best suitable quantitative analysis for testosterone?II. b) What is the difference between liquid-liquid, solid-liquid and solid-phase extraction? Complete the table below and sort the following examples in the correct column: Steeping tea, washing an organic phase (workup), brewing beer, chemical desalting of crude oil, activated carbon sugar decolorization. liquid-liquid solid-liquid solid-phase Phase that contains analyte before extraction? Phase that contains analyte after extraction? Example(s)
- Normality of a solution was determined by five different titrations. The results were 9.5 mL, 8.5 mL, 9.1 mL, 9.3 mL, and 9.1 mL. Calculate the mean, median and standard deviation of this dataThe protein concentration of a protein isolate was determined using the Bradford assay. Five dilution of bovine serum albumin (BSA) were prepared from a 5.00 mg/mL BSA stock solution. To these dilutions, 100 µl of Bradford reagent were added. After 5 minutes, the absorbance was taken at 595 nm. Standard # BSA, in mg/mL Volume of Bradford reagent, A595 in mL 1 5.0 0.000 1.00 5.0 0.134 3 2.00 5.0 0.265 4 3.00 5.0 0.388 4.00 5.0 0.497 The supernatant dilution was prepared by mixing 49 µL of the protein isolate with 16 µL water. The absorbance was taken 5 minutes after addition of 100 mL Bradford reagent. Calculate the protein concentration (in mg/mL) of the original isolate if the absorbance at 595 nm was 0.413. Note: Final answer format must be x.xxx (three decimal places). Round off only in the final answer. Do not round off in the middle of calculation.Give the standard deviation of these three molaritys. 0.0366 0.0373 0.0370