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Explain the following pairs of concepts and briefly describe their major difference(s)
1. RILs & DHLs.
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- Based on the analytical characteristics discussed, explain why the TSH result is reported this way (TSH ≤ 0.3 mU/L). Please answer if you, don't guess or put random answers, I'll put a thumbs down if the answer is not compliant with the question40. Use the diagram below for this question. In this research study, Jager et al. (Frontiers Psychiatry, 2019) used the elevated-plus maze test in mice to examine the effects of increasing doses of the psychostimulant known as methylphenidate (MPH). From the pictures and graph provided, what could they conclude? Elevated-plus maze test after acute treatment with methylphenidate (MPH) Time in Open Arms Venice Contra MPH 3mghg MPH 10 mg a. MPH significantly augmented anxiety in a dose-dependent manner. b. MPH significantly reduced anxiety in a dose-dependent manner. c. MPH significantly augmented depression in a dose-dependent manner. d. MPH significantly reduced depression in a dose-dependent manner. e. None of the above make sense.. % TotalTime MineWhat is the Minimum inhibitory concentrations (MIC) for each from 1 to 12 based on the picture:
- neurokinin-1 receptor antagonists known to inhibit the CYP3A4 enzyme. There is a potential drug drug interaction between lopinavir/ritonavir combination and aprepitant. Explain the potential pharmacokinetic consequences of the interaction on PK parameters of lopinavir and ritonavir following oral administration. AUC, apparent volume of distribution, clearance.Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)Which of the following is true of the absorption, distribution, and elimination of delta-9-tetrahydrocannabinol? Question 11 options: When ingested, THC is quickly and efficiently absorbed, and more than 30 percent reaches the brain within 10 minutes When smoked, the peak mood-altering and cardiovascular effects occur together, usually within 5-10 minutes When smoked, THC is rapidly distributed first to the heart and then absorbed into the blood, reaching the brain and the rest of the body When ingested, the peak mood-altering and cardiovascular effects occur between 40-60 minutes after ingesting
- What is the maximum allowable dosage of the most commonly used anesthetic solution i.e. 2% Lidocaine HCl with 1:100,000 epinephrine for a 52 kg healthy adult?An athlete tested positive for Methylhexaneamine in urine with a level of 0.90 µg/mL. At her appeal in the Court of Arbitration, she quotes a highly respected scientific publication that states that at levels of 1.0 µg/mL there is no performance enhancement. If the athlete’s levels are indeed below this threshold, the athlete can face a year’s suspension instead of a ban for life. Use the Estimate of Uncertainty to determine if the Athlete should be given a 1 year suspension or banned for life.Briefly explain these three facts:
- Explain the role, using diagrams wherever possible, of G protein coupled receptors mediating the following physiological effects. a. Positive inotropic and positive chronotropic effects in the heart b. Vasoconstriction in vascular smooth muscle cells.Kaurenoic acid is an active ingredient found in various plants, including stevia. Scientists investigated the pharmacokinetic profile of 50 mg/kg of kaurenoic acid in rats after intravenous (IV) vs oral administration. The plots below were obtained. Cp(mg/L) 25 20- 15- 10- 0 2 • 4 A 8 Cp(mg/L) 10 25- 20- 15- 6 6 Time (h) Time (h) Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route. 10- 5- 0+ 0 4 B 8 10 The IV plot could be fitted by the equation: Cp = 28 exp(-1.2t) - where Cp (mg/L) is the plasma concentration and t (h) the time after administration of a 50 mg/kg single dose.Long-distance runners (26.2 miles) describe Runner’s High as a feeling of euphoria. It is often described as a feeling of being invincible and individuals claim a lost sense of time while running. Runner’s high is believed to be caused by very small molecules called endocannabinoids released by the brain that affect the way a person feels, moves, and reacts. Based on the information above what you know of interacting systems, which of the following two are correct? A. If the release of endocannabinoid molecules is increased, the runner will not experience the feeling of euphoria and will stop running. B. The muscular system is not affected by the release of endocannabinoids, which are released by the nervous system. C. If the function of the nervous system is compromised and endocannabinoids are not released, the function of the muscular system is affected and prolonged endurance will be jeopardized. D. The release of endocannabinoids at the cellular level plays an indirect…