Ellis Engelsberg and his colleagues examined the regulation of genes taking part in the metabolism of arabinose, a sugar (E. Engelsberg et al. 1965. Journal of Bacteriology 90:946-957). Four structural genes encode enzymes that help metabolize arabinose (genes A, B, D, and E). An additional sequence C is linked to genes A, B, and D. These are in the order D- A- B- C. Gene E is distant from the other genes. Engelsberg and his colleagues isolated mutations at the C sequence that affected the expression of structural genes A, B, D, and E. In one set of experiments, they created various genotypes at A and C and determined whether arabinose isomerase (the enzyme encoded by gene A) was produced in the presence or absence of arabinose (the substrate of arabinose isomerase) by cells with these genotypes. Results from this experiment are shown in the following table, where a plus sign (+) indicates that the arabinose isomerase was synthesized and a minus sign (-) indicates that the enzyme was not synthesized. Arabinose Arabir Genotype absent prese 1. C* A* 2. C A* 3. C A*/C* 4. CA/C A*
Ellis Engelsberg and his colleagues examined the regulation of genes taking part in the metabolism of arabinose, a sugar (E. Engelsberg et al. 1965. Journal of Bacteriology 90:946-957). Four structural genes encode enzymes that help metabolize arabinose (genes A, B, D, and E). An additional sequence C is linked to genes A, B, and D. These are in the order D- A- B- C. Gene E is distant from the other genes. Engelsberg and his colleagues isolated mutations at the C sequence that affected the expression of structural genes A, B, D, and E. In one set of experiments, they created various genotypes at A and C and determined whether arabinose isomerase (the enzyme encoded by gene A) was produced in the presence or absence of arabinose (the substrate of arabinose isomerase) by cells with these genotypes. Results from this experiment are shown in the following table, where a plus sign (+) indicates that the arabinose isomerase was synthesized and a minus sign (-) indicates that the enzyme was not synthesized. Arabinose Arabir Genotype absent prese 1. C* A* 2. C A* 3. C A*/C* 4. CA/C A*
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter15: From Dna To Protein
Section15.1: The Connection Between Dna, Rna, And Protein
Problem 1SB
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