Discuss the difference between first-generation and second-generation antihistamines
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Discuss the difference between first-generation and second-generation antihistamines.
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- What are the potential implications of genetic variations in drug-metabolizing enzymes on individual response and therapeutic outcomes in clinical pharmacology?How does physicochemical properties of a drug define its biological mechanism? Please explain at your own words.▪ A patient arrives at the ER complaining of seizures. The patient is taking phenytoin as prescribed which has a therapeutic range of 10-20 ug/mL. You order the SDC and find it is 8 ug/mL at steady state. This is an indication that A) dose needs to be increased. The dose needs to be individualized. ▪ B) The patient is noncompliant.
- For each of the following pharmacologic classification of antihypertensive agents, list (a) at least three (3) molecules as examples with (b) corresponding Brand/ Proprietary Names, and (c) two (2) adverse effects (avoid repetition):For each of the following drugs, indicate whether the physiological effects of the drug were known before or after the target was identified. a. Penicillin b. Sildenafil (Viagra) c. Rofecoxib (Vioxx) d. Atorvastatin (Lipitor) e. Aspirin f. Indinavir (Crixivan)How we can improve pharmacodynamic parameters for the development of H1-Antihistamine ? Discuss