Different cell-types can use the same receptor-type to detect a common hormone, which leads to the abilitiy of that hormone to trigger multiple physiological responses. A. True B. False
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Different cell-types can use the same receptor-type to detect a common hormone, which leads to the abilitiy of that hormone to trigger multiple physiological responses.
A. True
B. False
Hormones are small molecules that act as chemical messengers in the body. A small amount of hormone can have great physiological effect.
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- When comparing two or more ligands, a larger numerical value for KD corresponds to a higher binding affinity. True False In radioligand binding assays, a large excess of a noncompetitive antagonist is used to determine the specific binding of the radiolabeled ligand. True False Exocrine glands have ducts that provide a passageway for secretions to move to the surface of the epithelium. True False An inverse agonist binds to a receptor with an affinity that is inversely proportional to its potency. True False Can I get the answer? I don't need explanation. Hedgehog, the signal, does not travel very far to bind to its receptor, Patched, on target cells.Therefore, target cells that are closer to the signaling cell receive a stronger signal. What modeof signaling does this describe?A. EndocrineB. Paracrine/AutocrineC. SynapticD. Contact-dependentExplain:John is told that he has a hormone receptor problem and his cells are not responsive to hormone stimulation. Which of the following is a possible reason for his problem? Select one: A. He has an ectopic tumor. B. He has hypersensitivity to the hormone. C. He has a receptor that has been overstimulated. D. He has too many receptors for the hormone. E. He has antibodies that block the function of the hormone receptor. O O O O
- Identify which of the following statements is a lie? Select one: a. The docking of ligands to the receptor causes receptor-associated proteins to activate another protein to continue the signaling cascade and one example of this event is the binding of epidermal growth factor (EGF) to the EGF receptor . b. Ligands are important to initiate signal Transduction pathway. c. Ligands detach from the cell surface receptor in order to change the conformation of the receptor and initiate the signaling pathway.Describe intracellular receptors, using estrogen receptors as anexampleWhat is the principal difference of endocrine system from other signaling systems? Select one: A. Endocrine signals diffuse to neighboring target cells. B. Endocrine signals produce self-activation of the secreting cells. C. Endocrine system uses cell-cell contact to transduce signals. D. Endocrine signals are delivered by blood. E. Endocrine signals always generate faster responses in target cells.
- Describe how ligand binding to a receptor leads to the production of IP3 and DAG and the release of Ca2+.You are working in a lab to examine the cellular responses to a new drug. You treat cells with the drug and measure the intracellular level of cAMP and find it to be increased in response to this treatment. With what type of receptor would you predict the drug interacts? How is this rise in cAMP used to change cellular physiology or metabolism?Name the steps that occur when a signal binds to a receptor on a responding cell.
- Describe three ways in which a gradual increase inan extracellular signal can be sharpened by the target cellto produce an abrupt or nearly all-or-none response.A new antagonist molecule has been discovered that binds to and blocks plasma membrane receptors. What effect will this antagonist have on testosterone, a steroid hormone? a. It will block testosterone from binding to its receptor. b. It will block testosterone from activating cAMP signaling. c. It will increase testosterone-mediated signaling. d. It will not affect testosterone-mediated signaling.Describe three different responses of a cell-surfacereceptor on binding a signaling molecule and undergoing aconformational change.
