Describe one chemotherapeutic approach that can be used to treat prostate cancer? Your answer should include information about the molecular processes and interactions which are at the core of the treatment strategy
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- Describe one chemotherapeutic approach that can be used to treat prostate cancer? Your answer should include information about the molecular processes and interactions which are at the core of the treatment strategy
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- For many years, targeted therapies for cancer treatment continue to be developed, however more and more patients are developing resistance to targeted therapies. Discuss one mechanism of resistance to targeted therapies for cancer and provide an example of how might creatively combat it using clinical concepts.BiDil® is indicated for the treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, to prolong time to hospitalization for heart failure, and to improve patient-reported functional status Question: The results of BiDil® clinical trials were compelling…Expound on the results. Question : What role did FDA’s approval resulted in BiDil® being a great example of pharmacogenomics/pharmacogenetics in the U.S.?Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.
- Using Excel, analyse your data and draw a graph of the percentage cell growth versus concentration of anti-cancer drug using the results obtained by the CVDE and AP methods. Comment on the results.What are best examples for a cancer program planning component by using a logic modelCold allodynia is a common side effect of platinum-based chemotherapy drugs. Define this term.
- Discuss why cancer treatment may involve a combinationof chemotherapy, radiation therapy, and surgery.why is LDHA an attractive target for a cancer therapeutic? https://www.nature.com/articles/s41598-019-40617-3#Tab1Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. There are many biomedical engineering based approaches to detect CSCs. Question: What kind of systems have been developed to detect CSCs? Describe by giving examples. Please explain in detail the main findings with your own words.
- List several reasons why angiogenesis is a very active area for cancer therapy research.Distinguish between What is known of CD105 (endoglin) as an hepatcellular carcinoma marker and it’s potential as a drug target. Discuss: - Is anything known about its biology? E.g does it have known ligands and normal functions? - if you were to target it would you just use it to get growth inhibiting compound into the new blood vessels or is CD105 required for neovascularization?The following are words used in animal testing and its alternative methods. Define the following terms - a. Vivisection b. Optogenics c. In vivo d. In vitro cell culture e. In silico computer simulation f. Pharmacokinetics g. Pharmacodynamics h. Tissue culture i. Phototoxicity j. 3D cell cultures