Consumption of dinitrophenol by animals results in an immediate increase in body temperature. Explain the phenomenon.Why should this decoupler not be used as a diet aid?
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Consumption of dinitrophenol by animals results in an immediate increase in body temperature. Explain the phenomenon.
Why should this decoupler not be used as a diet aid?
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- Consumption of dinitrophenol by animals results in an immediate increase in body temperature. Explain the phenomenon. Why is dinitrophenol not used as a diet aid?This is about the application Le Chatelier's Principle to Thermoregulation and Homeostasis within humans. Apply the concept of Le Chatelier’s Principle and discuss how it works:In healthy adults, the concentration of glucose in blood is approximately80 to 110 milligrams per deciliter (mg/dl). After a carbohydrate-richmeal, however, the concentration may spike to 140 mg/dl. Describe thehormonal action that returns blood glucose to normal.
- List two classes of compounds derived from arachidonic acid. Suggest some reasons for the amount of biomedical research devoted to these compounds.Explain why excess mevalonate is present in the blood and urine?Hemoglobin molecules exposed to high levels of glucose areconverted to glycated products. The most common, referred to as hemoglobin A1C (HbA1C), contains a b-chain glycatedadduct. Because red blood cells last about 3 months, HbA1Cconcentration is a useful measure of a patient’s blood sugarcontrol. In general terms, describe why and how HbA1Cforms.
- Describe thermoregulation in humans (i.e. what happens when body temperature falls or rises beyond the tolerance range?)During times of prolonged fasting, ketone bodies such as ß-hydroxybutyrate build up in plasma. As a result, this causes a decrease in pH. This condition is calledYears ago there was interest in using uncouplers such as dinitrophenol asweight control agents. Presumably, fat could be oxidized without concomitant ATP synthesis for re-formation of fat or carbohydrate. Why was this a bad (i.e., fatal) idea?
- Valinomycin is an ionophore antibiotic that renders biological membranes permeable to K+. Its side effects in patients with bacterial infections include a rise in body temperature and sweating. Explain.Ketone bodies that build up under starvation conditions act as hunger suppressants and mentaldepressants. Does this make sense or would it make more sense for them to act as a stimulant to goout and find food? Explain.Many patients with glucose 6- phosphatase deficiency have high serum levels of urate. Hyperuricemia can be induced in normal people by the ingestion of alcohol or by strenuous exercise. Propose a common mechanism that accounts for these findings.