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Compare the mechanisms and the effects of loop diuretics, thiazide diuretics, ACE inhibitors, and ARBs (angiotensin II receptor blockers)
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- How carbonic anhydrase inhibitors act as diuretics? Briefly explain at your own wordsDuring treatment of congestive heart failure and hypertension, describe the mechanism of action and major side effects of loop diuretics, ACE inhibitors, blockers, and Ca2+ channel blockers.What do you mean by pharmacokinetic and pharmacodynamic drug development of diuretic drugs? Explain at your own words
- What are major advantages and disadvantages of diuretics use? What are major site effects and drug interactions? Give some examples. A 51-year-old man asks his physician for a prescription for sildenafil to improve his sexual performance. Because of risks from a serious drug interaction, this drug should not be prescribed and the patient should be urged not to try to obtain it from other sources, if he is also taking which of the following drugs? Angiotensin-converting enzyme inhibitor Beta-adrenergic blocker Nitrovasodilator (eg. Nitroglycerin) Thiazide or loop diureticBriefly discuss the drug development of diuretics drugs? Please discuss at your own wordsAll of the following medications augment activity of sulfonylureas, except:A. Anabolic steroidsB. ACE inhibitorsC. SalicylatesD. Loop diureticsE. Tetracyclines
- Diuretics can be prescribed to combat high blood pressure. Thiazide is one of the most common. Describeits mechanism of action (they physiology of what the drug does) and how it combats high blood pressure. The action of the diuretic Thiazide can also cause the activation of the renin-angiotensin system. Explain this system (starting with renin) and whyit would be counterproductive to the reason you prescribed Thiazide for a patient. i only need answer for the question 2 Please!Describe the mechanism of action of diuretics most commonly used for hypertension treatment. What are the major side effects and drug-drug interactions?Why do site-IV diuretic drugs administer with the combination of site-I, site-II and site-III diuretic drugs ? briefly explain at your own words
- An investigator is studying renal physiology in patients with type 1 diabetes mellitus. When a substance that inhibits glucose reabsorption is given, which of the following best describes the clearance of glucose?a. Decreases and approaches the clearance of p-aminohippurateb. Decreases and approaches the clearance of inulinC. Increases and approaches the clearance of p-aminohippurated. Increases and approaches the clearance of inuline. Increases and approaches the clearance of sodiumA common side effect of loop diuretics is hyponatremia. Which of the following compound would be given to best treat this? * Canreone Tolvapatan Triametrene Amiloride O Spironolactone1. 3 of the following are true of the Renin Angiotensin Aldosterone System (RAAS) A. The JG cells are located at the distal collecting tubule B. The Juxtaglomerular cells (JG cells) are modified smooth muscles in the afferent arteriole C. The Macula densa detects osmolality of the filtrate D. The Macula densa is made up of tall columnar cells 2. 2 of the following are true of the RAAS responding to a decrease in Na in the filtrate A. Macula densa detects the decrease in osmolality B. JG cells are stimulated by Macula densa through tight junctions C. Aldosterone stimulates principal cells of collecting tubule to reabsorb water D. Aldosterone reabsorbs Na and by osmotic forces increase fluid in the extracellular compartment 3. 2 of the following are true of the loop of Henle A. Descending thick limb is also called the pars recta of the proximal tubule B. The function of the descending thick limb is similar to the distal convoluted tubule C. Cells of the descending thin limb are very…
