Chromosomal DNA (human) 41% G + C Satellite DNA CAG repeat 67% G + C Shear during DNA isolation Centrifuge to equilibrium in CsCI Density A260 Bottom Top A FIGURE 21.4 Satellite DNA. Shearing high-molecular-weight DNA yields short fragments that have distinctive densities and can be sepa- rated in a CsCI gradient.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
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Huntington’s disease is a hereditary central nervous system disorder characterized by tandem repeats of the sequence 5'-CAG-3' in the gene that encodes a protein called huntingtin. The disease is progressive from generation to generation, meaning that in later generations the number of CAG repeats increases and the age of onset of symptoms decreases. Refer to Figure 21.4 and describe the sort of evidence supporting the generational increase in the number of CAG repeats.

Chromosomal DNA
(human)
41% G + C
Satellite DNA
CAG repeat
67% G + C
Shear during DNA isolation
Centrifuge to
equilibrium in CsCI
Density
A260
Bottom
Top
A FIGURE 21.4 Satellite DNA. Shearing high-molecular-weight DNA
yields short fragments that have distinctive densities and can be sepa-
rated in a CsCI gradient.
Transcribed Image Text:Chromosomal DNA (human) 41% G + C Satellite DNA CAG repeat 67% G + C Shear during DNA isolation Centrifuge to equilibrium in CsCI Density A260 Bottom Top A FIGURE 21.4 Satellite DNA. Shearing high-molecular-weight DNA yields short fragments that have distinctive densities and can be sepa- rated in a CsCI gradient.
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