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Carbohydrates can play important roles by modulating interactions between proteins. For example, Figure 7-27 (7th ed) shows how heparin (repeating unit of glycosaminoglycan, see Figure 7-22) binding can modulate the interaction between thrombin and anti- thrombin. What role do the sulfates of heparin play in stabilizing this complex, and what is the consequence of that stabilization? Select one: O a. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. b. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade. O c. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. O d. The sulfates bind to pockets on both proteins lined with glycine and proline residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade.

Carbohydrates can play important roles by modulating interactions between proteins. For example, Figure 7-27 (7th ed) shows how heparin (repeating unit of glycosaminoglycan, see Figure 7-22) binding can modulate the interaction between thrombin and anti- thrombin. What role do the sulfates of heparin play in stabilizing this complex, and what is the consequence of that stabilization? Select one: O a. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. b. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade. O c. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. O d. The sulfates bind to pockets on both proteins lined with glycine and proline residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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(a) Syndecan *NH3 Нерaran sulfate Chondroitin sulfate Outside Inside -0c (b) Heparan sulfate - NA domain S domain GlcNAc GlcA GlcNS IdoA 1 2-0-sulfate 1 6-0-sulfate
Transcribed Image Text:(a) Syndecan *NH3 Нерaran sulfate Chondroitin sulfate Outside Inside -0c (b) Heparan sulfate - NA domain S domain GlcNAc GlcA GlcNS IdoA 1 2-0-sulfate 1 6-0-sulfate
Carbohydrates can play important roles by modulating interactions between proteins. For example, Figure 7-27 (7th ed) shows how heparin (repeating unit of glycosaminoglycan, see Figure 7-22) binding can modulate the interaction between thrombin and anti- thrombin. What role do the sulfates of heparin play in stabilizing this complex, and what is the consequence of that stabilization? Select one: The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. а. b. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade. c. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. d. The sulfates bind to pockets on both proteins lined with glycine and proline residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. е. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade.
Transcribed Image Text:Carbohydrates can play important roles by modulating interactions between proteins. For example, Figure 7-27 (7th ed) shows how heparin (repeating unit of glycosaminoglycan, see Figure 7-22) binding can modulate the interaction between thrombin and anti- thrombin. What role do the sulfates of heparin play in stabilizing this complex, and what is the consequence of that stabilization? Select one: The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. а. b. The sulfates bind to pockets on both proteins lined with glutamate and aspartate residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade. c. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. d. The sulfates bind to pockets on both proteins lined with glycine and proline residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex activates the protease (thrombin), initiating the coagulation cascade. е. The sulfates bind to pockets on both proteins lined with arginine and lysine residues. The binding of heparin and the stabilization of the thrombin-anti-thrombin complex keeps the protease (thrombin) from initiating the coagulation cascade.
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