BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: How might BPA interact with the cell cycle and its checkpoints?
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BPA is a chemical compound that has historically been used in the
manufacture of plastic products. However, cells often mistake BPA
compounds for hormones that accelerate the cell cycle. Because of
this, BPA is associated with an increased risk of certain cancers.
Question: How might BPA interact with the cell cycle and its checkpoints?
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- BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: Why do you think that very small concentrations of BPA mighthave a large effect on the cell?"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? ExplainIn the following study, the investigators wanted to determine the role of cyclin B in controlling the cell cycle. Earlier researchers had found that extracts made from frog eggs (Xenopus) contained all the necessary proteins and machinery required for DNA replication. This included proteins that regulated the mitosis promoting factor (MPF). At the time of this study, cyclin B was show to affect MPF activity and the research group wanted to test using Xenopus egg extract in an assay. In Figure 1 (a) MPF activity was tested for its ability to phosphorylate Histone (H1) in sperm chromatin over a certain period of time. Additionally, the cyclin B concentration in the extract was measured. In figure 1b, the extract was tested after treatment with RNase which degraded only the mRNA and not RNA or FRNA in the extract. Knowing that cyclin B is a short-lived protein, why do you suppose the graph shows the results you see in figure 1b?
- Briefly describe the cell cycle, its checkpoints, and the general proteins required to move past each checkpoint. For each cell cycle checkpoint, be sure to describe what the cell is "checking for" and how this "check" occurs, along with the result if the checkpoint cannot be passed. Your answer should also include a description of the structure of MPF, its regulation, and its general targets or functions. Be sure to include any accessory molecules or proteins involved in regulation of MPF, while also describing the process by which MPF is formed and activated. In this answer, you should also choose two proteins involved in the cell cycle, which, if mutated, will cause cancer. Describe these proteins and their normal functions, and then show how a mutation in these proteins will result in cancer.Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation."Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.
- BPA is a chemical compound that has historically been used in the manufacture of plastic products. However, cells often mistake BPA molecules for hormones that accelerate the cell cycle. Because of this, BPA is associated with an increased risk of certain cancers.a. How might BPA interact with the cell cycle and its checkpoints?b. Why do you think that very small concentrations of BPA might have a large effect on a cell?(b) What is the role of microtubules in mitosis? How does vincristine contribute to the cell cycle arrest of cancer cells? Explain. MicrotubulesDuring cell division cycle, cells need to monitor the process of DNA replication and segregation of replicated DNA so that these processes are error-free. Some potential errors that could occur include incomplete DNA replication, DNA damage in genome, and uneven separation of replicated genome. These mechanisms that cells used to monitor these processes are referred as the "cell cycle checkpoint, which can control specific Cdk activity to regulate the progression of cell cycle. For the following checkpoint mechanisms, indicate which Cdk activity is attenuated? Also indicate one of the key proteins or protein complexes involved in the following checkpoints. a) DNA damage checkpoint during S-phase b) Mitotic checkpoint during M-phase
- The process of cellular reproduction or divisions is a heavily regulated process for a number of different reasons. In the case of the eukaryotic cell there are a number of different checkpoints that a cell must pass before it can continue on. Please explain what those checkpoints are looking for and where those checkpoints are in the cell cycle. If a cell doesn’t pass any of these checkpoints what happens to those cells?How does the dysregulation of cell cycle checkpoints contribute to the development of cancer?Cell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?