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An experiment was done : Synthesis of a potential enzyme inhibitor The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.

An experiment was done : Synthesis of a potential enzyme inhibitor The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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An experiment was done : Synthesis of a potential enzyme inhibitor

The product achieved from the experiment was 4.0g. Using the picture provided determine the percentage yield.

 

 

Add 3g of 4-hydroxyacetophenone to 70ml anhydrous dichloromethane in a 250cm³ round bottom flask. Then add 5ml of triethylamine and stir the mixture for a 1 minute. Cool the mixture to 0°C in an ice bath and add 3ml of methane sulfonyl chloride whilst stirring the solution by hand using a glass rod. Add 2-4 anti-bumping granules. Using a heating mantle, reflux the reaction mixture for 45 minutes. After cooling to room temperature, carefully pour the reaction mixture into a beaker containing approximately 100cm³ of ice. After the ice has melted, wash the dichloromethane layer twice with water (50ml each time). Wash the dichloromethane twice with saturated sodium bicarbonate (NaHCO3) solution (50ml each time) and finally once with water (80ml). Dry the dichloromethane layer over anhydrous magnesium sulfate. After filtering off the solid magnesium sulfate, remove the dichloromethane using a rotary evaporator. You should avoid smelling the product as there may still be some residue of methane sulfonyl chloride present in the round bottom flask. Record the weight and therefore determine the percentage yield. 15
Transcribed Image Text:Add 3g of 4-hydroxyacetophenone to 70ml anhydrous dichloromethane in a 250cm³ round bottom flask. Then add 5ml of triethylamine and stir the mixture for a 1 minute. Cool the mixture to 0°C in an ice bath and add 3ml of methane sulfonyl chloride whilst stirring the solution by hand using a glass rod. Add 2-4 anti-bumping granules. Using a heating mantle, reflux the reaction mixture for 45 minutes. After cooling to room temperature, carefully pour the reaction mixture into a beaker containing approximately 100cm³ of ice. After the ice has melted, wash the dichloromethane layer twice with water (50ml each time). Wash the dichloromethane twice with saturated sodium bicarbonate (NaHCO3) solution (50ml each time) and finally once with water (80ml). Dry the dichloromethane layer over anhydrous magnesium sulfate. After filtering off the solid magnesium sulfate, remove the dichloromethane using a rotary evaporator. You should avoid smelling the product as there may still be some residue of methane sulfonyl chloride present in the round bottom flask. Record the weight and therefore determine the percentage yield. 15
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