Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C) COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter16: Chemistry Of Benzene: Electrophilic Aromatic Substitution
Section16.4: Substituent Effects In Electrophilic Substitutions
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Given this retrosynthetic analysis, propose a synthesis for haloperidol.

Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol
(Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system.
но
Haloperidol
Br.
(A)
1-Bromo-4-chlorobenzene
COOCH3
COOCH,
COOCH
(В)
(C)
Transcribed Image Text:Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C)
COOCH, +
NH2
Methyl acrylate
THN
Fluoro-
Succinic
(F)
benzene
anhydride
(E)
Transcribed Image Text:COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)
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