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Low doses of aspirin are commonly used to reduce the risk of arterial thrombosis in patients who have suffered myocardial infarction. Which one of the following steps in hemostasis is inhibited by aspirin?
- Aggregation of platelets|
- Adhesion of platelets to collagen
- Production of tissue factor
- Synthesis of von Willebrand factor
- Synthesis of antithrombin III|
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Solved in 3 steps
- Hyperglycemia associated with diabetes promotes a prothrombotic state by affecting a number of different steps in the clotting pathway. Which of the following would result in more rather than less clotting? Check all that apply. The correct answers reflect the effect of hyperglycemia on the clotting pathway! less conversion of plasminogen to plasmin 7 000000000 abnormally low number of platelets platelets more sensitive to thromboxane A2 elevated conversion of plasminogen to plasmin platelets less sensitive to thromboxane A2 low sensitivity to NO and PGI2 increased prothrombin in the blood increased amount of fibrinogen in the blood less prothrombin in the blood abnormally high number of platelets less fibrinogen in the blood high sensitivity to NO and PGI2A direct thrombin inhibitor would impact which of the following processes? Currently Selected : B A Fibrin D-dimer formation В Factor X activation C Plasminogen activation Platelet activationHeparin is an activator of antithrombin III. In addition to thrombin, which additional coagulation factors are targeted by the antithrombin IlI:heparin complex? Currently Selected : B A Factor X В Factor VII Factor VIII Factor V
- One of the more common adverse effects of cancerchemotherapy is the destruction of leukocytes. Before hisnext scheduled chemotherapy treatment, a patientundergoes a blood test called an absolute neutrophil count(ANC), which reveals that his neutrophil count is 1900 cells per microliter. Would his healthcare team be likely toproceed with his chemotherapy treatment? Why?Which of the following is not an extensive property The combination of equivalent amounts of acids and bases is called? What is the correct sequence of the different stages in blood clotting? I Fibrinogin thrombin fibrin/II Prothrombin thromboplastin Thrombin CaDiscuss the sequence of events involves in the formation of platelet plug following platelet adhesion.
- It is known that heparin acts by increasing the activity of antithrombin, causing a conformational change. LMWHs inhibit mainly factor Xa. Although low doses of heparin act primarily by neutralizing factor Xa, at high doses it prevents thrombin-induced platelet activation and prolongs bleeding time. What are major clinical benefits using heparin or LMWHs?Which of the following are mechanisms which prevent clotting under normal circumstances? Select all that apply. platelets are not released into the bloodstream until needed heparin and anti-thrombin circulate in the bloodstream vessels are coated with prostacyclin which repels platelets clotting enzymes are not released into the bloodstream until needed rapid blood flowWhich is the correct sequence of steps m tne final common pathway of blood clot formation? prothrombin thrombin thrombin; fibrinogen → fibrin fibrinogen a) > prothrombin; fibrin prothrombin → fibrinogen; thrombin fibrin; prothrombin fibrinogen; thrombin > fibrinogen fibrin fibrin → thrombin → prothrombin e) Lactate dehydrogenase (LDH) is a classic example of an enzyme regulated by isozymes. The B4 isozyme of LDH uses lactic acid in aerobic conditions to generate a large amount of ATP energy. Which of the following tissues contains predominantly the B4 isozyme? skeletal muscle b) liver white cells heart muscle e) brain
- Rho activation is preceded by association of a Rho regulator to regions of the plasma membrane just “above” where the contractile ring will form. Which regulator (Rho GAP or Rho GEF) would you predict would be localized to this region of the cell? Briefly explain your reasoning.Select all the options below which are false of hemostasis. | aspirin is an effective "blood thinner" (anticoagulant) because it prevents the formation and release of ADP by platelet plugs | after damage to a vessel, the immediate reaction is vasodilation to bring more white blood cells in and prevent infection O factor X is the converging point of both the intrinsic and extrinsic pathways of the clotting cascade when platelets begin to aggregate, a negative feedback loop begins to cause more platelets to aggregatePlatelet-platelet binding and aggregation requires the interaction of fibrinogen with a receptor on activated platelets. Which of the following is the most likely composition of the receptor Factor XII(Hageman factor) Glycoprotein 1b/IX Glycoprotein 11b/11a Plasmin Thrombin Von Willebrand factor