A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one

A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter10: Biotechnology

Section: Chapter Questions

Problem 13CTQ: Identify a possible advantage and a possible disadvantage of a genetic test that would identify...

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A DVT (deep vein thrombosis) clinic had 320 persons appearing for lower extremities Doppler ultrasound study. If 48 out of 80 subjects with DVT tested positive for the DVT, and 228 out of 240 without DVT tested negative Calculate the following Sensitivity Specificity False positive False negative Positive predictive value (PPV) What does this PPV mean Negative predictive value (NPV) What does this NPV here mean The prevalence of DVT What is the 2 x 2 contingency table What is the difference between prevalence with regard to PPV and NPV?
The Physicians' Health Study was a randomized, double-blind, placebo-controlled trial of 22,071 apparently healthy male physicians. Subjects were randomized into two groups: one group took a buffered aspirin every other day and the other was given a placebo. The average follow-up during the aspirin component of the trial was 60.2 months. Baseline cardiovascular risk factors and adherence to therapy during the trial were assessed by questionnaire. Cardiovascular outcomes were reported by questionnaire and confirmed by record review by an Endpoints Committee. Among those taking the aspirin, 104 heart attacks (with five deaths) occurred compared to 189 heart attacks 18 of them fatal among those taking the placebo. The study was terminated early, due principally to a 44% reduction in the risk of a first myocardial infarction (MI). Which of the following are NOT a reason(s) to use a placebo in this trial? Select all that apply. To ensure the ethical review board will approve the…
write a summary :Currently used animal and cellular models for pulmonary arterial hypertension (PAH) only partially recapitulate its pathophysiology in humans and are thus inadequate in reproducing the hallmarks of the disease, inconsistent in portraying the sex-disparity, and unyielding to combinatorial study designs. Here we sought to deploy the ingenuity of microengineering in developing and validating a tissue chip model for human PAH. We designed and fabricated a microfluidic device to emulate the luminal, intimal, medial, adventitial, and perivascular layers of a pulmonary artery. By growing three types of pulmonary arterial cells (PACs)-endothelial, smooth muscle, and adventitial cells, we recreated the PAH pathophysiology on the device. Diseased (PAH) PACs, when grown on the chips, moved of out their designated layers and created phenomena similar to the major pathologies of human PAH: intimal thickening, muscularization, and arterial remodeling and show an endothelial to…
when v=vmax/2，Km =（S） 1.why？？Need Explaination. What is V and what is Vmax？how is their relationship and how they affect each other？Detail explanation please. The Fomular：V/E total = K cat. 2. What Is E total？？？need definition of E total.Detail explanation please.
A case-control study was conducted to evaluate the relationship between physical activity and coronary heart disease (CHD) in men. A total of 406 men newly diagnosed with CHD were included together with 406 men of similar ages who did not have CHD. The risk of CHD (measured by the OR) was higher among men who were inactive or only moderately active (collectively called ‘inactive’) than among those who were physically active: (See attached image) Odds ratio for inactive men compared to active men= (299 x 136)/(270 x 107)=1.41Suppose there is no misclassification in these data.What would the observed OR have been... 1. If 20% of all the inactive men had been misclassified as active? 2. If 10 % of inactive cases had been misclassified as active?
Answer the following questions using data from the figure above. a. What is the overall treatment effect? b. Provide a written interpretation of the treatment effect and 95% confidence interval. Support you answer with data from the table above. c. Would you implement the intervention (YES or NO)? Provide rationale for your answer considering the spheres of the EIDM model.
1) Explain the principle of the electrical impedance cell counting. 2) State 3 Haematology analyzer and their manufacturers. 3) CV for automated instrument is +/- 1% to +/- 2% compared to manual count with CV +/- 10%. Can you explain their differences?
-t=449595&cmid=1668389 textb... My ATI NOLOGY SUPPORT ✓ MTH 208-01 (MW... K Kaplan Login WP WileyPLUS VitalSource Books... Zika virus is chiefly spread using an insect vector, more specifically, mosquitoes. Given this, which of the following helps account for why all blood donations in J.S. are screened for Zika? O a. Zika can be easily transmitted from person to person even through incidental contact O b. Zika infections are now common and regularly reported in every U.S. State (except Alaska) O c. Screening of blood donations is the main way in which Zika infections are diagnosed in the U.S. O d. Climate change extends the habitat of mosquitoes that can carry the virus Next page
Out of the experimental designs, two-group pretest-posttest design, two-group posttest design, Solomon four-group design, multiple experimental group design, and factorial design. Which of these would be best for researching the impact of diet on hypertension? What makes that design a better choice?
What do you think about the longitudinal NIH-funded Bogalusa Heart Study, created by cardiologist Gerald Bevenson in 1972? This study is following 16,000 who started in childhood and are now adults (40 years thus far). Researchers have looked at several things, on those living, as well as performing autopsies on 560 of these individuals who died since then (of accidental death or otherwise). 20% of autopsied children had plaques (fat deposits) in their coronary arteries, making this the first study of its kind to establish heart disease can exist in children, and those who were obese as children were likely to remain so in adulthood, as opposed to only 7% becoming obese who were not so in childhood.
In a placebo-controlled study, 10 healthy subjects were given oral triazolam 0.5 mg before and after rifampicin 600 mg daily for 5 days. Rifampicin reduced the triazolam AUC by 95% and decreased its maximum plasma levels by 88%, when compared with placebo. The elimination half-life was reduced from 2.8 hours to 1.3 hours. Pharmacodynamic tests (drowsiness, sway, Maddox wing, etc.) showed that rifampicin abolished the effects of triazolam.a) Why is the AUC of triazolam reduced in the presence of rifampicin? b) Given the above scenario, if you were to accommodate this situation by dosage adjustment strategies, in the presence rifampicin what dose of triazolam would you have recommended, keeping dosage interval the same as when there was no rifampicin? answer part b
DARK DARK CHOCOLATE A CHOCOLATE B Average systolic reading (mmHg) 117 110 68% of area Calculated value of 95% of area "1" Standard.Dev. + 3.38 + 7.97 (mmHg) 99.7% of area -3 -2 -1 For normally distributed data: 68% of the individual data values are within + "1" standard deviation of the mean. 95% of the individual data values are within + "2" standard deviations of the mean 99% of the individual data values are within + "3" standard deviations of the mean The values listed in the table above are for + "1" standard deviation. Add and subtract these 0thb values to and from the sample mean to gain a better appreciation for the blood pressures of the 09to975 individuals in each study. 811 values from the table above to Chocolate A: 68% of individuals had a blood pressure reading of (117 – 3.38) (117 + 3.38) 95% of individuals had a blood pressure reading of *+2 standard deviations, or twice the reported value to (117- 6.76) (117 + 6.76) use the values for tChocolate B: 68% of individuals…