A C-terminal KDEL tetrapeptide was identified by “sequence gazing” as a possible signal for keeping resident ER proteins in the ER. This idea is now described in your textbook as established fact. What types of experiments do you think were performed to confirm that KDEL serves as an ER localization signal?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A C-terminal KDEL tetrapeptide was identified by “sequence gazing” as a possible
signal for keeping resident ER proteins in the ER. This idea is now described in your
textbook as established fact. What types of experiments do you think were performed
to confirm that KDEL serves as an ER localization signal?

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