A 52-year-old woman comes to the physician because of diffuse itching that has worsened over the past 2 weeks. Physical examination shows jaundice and an enlarged, firm liver. Laboratory studies of serum show: Total cholesterol: 620 mg/dL Alkaline phosphatase: 502 U/L AST: 120 U/L ALT: 75 U/L Anti-smooth muscle antibody: negative Antinuclear antibody: negative Antimitochondrial antibody: 1:1280 (N=negative) Which of the following pathologic findings is most likely in a biopsy specimen of her liver? Eosinophilic globules in the periportal hepatocytes. Granulomatous inflammation of hepatic bile ducts Hepatocellular carcinoma Hepatocellular necrosis with Mallory bodies Macrovesicular hepatocellular steatosis

A 52-year-old woman comes to the physician because of diffuse itching that has worsened over the past 2 weeks. Physical examination shows jaundice and an enlarged, firm liver. Laboratory studies of serum show: Total cholesterol: 620 mg/dL Alkaline phosphatase: 502 U/L AST: 120 U/L ALT: 75 U/L Anti-smooth muscle antibody: negative Antinuclear antibody: negative Antimitochondrial antibody: 1:1280 (N=negative) Which of the following pathologic findings is most likely in a biopsy specimen of her liver? Eosinophilic globules in the periportal hepatocytes. Granulomatous inflammation of hepatic bile ducts Hepatocellular carcinoma Hepatocellular necrosis with Mallory bodies Macrovesicular hepatocellular steatosis