A 30-year-old woman has had mild fatigue for many years. Physical examination reveals a palpable spleen tip. Laboratory studies show Hgb 11.1 g/dL, Hct 28.8%, MCV 77 fL, platelet count 229,000/microliter, and WBC count 7340/microliter. Her reticulocyte count is 3.9%. Examination of her peripheral blood smear shows RBCs which are elliptical. Which of the following is the most likely pathology of this disease? Defect in Phospholipid bilayer Defect in Spectrin and band 4.1 Abnormal sodium pump Deficiency of pyruvate kinase Abnormal Ankyrin or band 3.1
A 30-year-old woman has had mild fatigue for many years. Physical examination reveals a palpable spleen tip. Laboratory studies show Hgb 11.1 g/dL, Hct 28.8%, MCV 77 fL, platelet count 229,000/microliter, and WBC count 7340/microliter. Her reticulocyte count is 3.9%. Examination of her peripheral blood smear shows RBCs which are elliptical. Which of the following is the most likely pathology of this disease? Defect in Phospholipid bilayer Defect in Spectrin and band 4.1 Abnormal sodium pump Deficiency of pyruvate kinase Abnormal Ankyrin or band 3.1
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A 30-year-old woman has had mild fatigue for many years. Physical examination reveals a palpable spleen tip. Laboratory studies show Hgb 11.1 g/dL, Hct 28.8%, MCV 77 fL, platelet count 229,000/microliter, and WBC count 7340/microliter. Her reticulocyte count is 3.9%. Examination of her peripheral blood smear shows RBCs which are elliptical. Which of the following is the most likely pathology of this disease?
- Defect in Phospholipid bilayer
- Defect in Spectrin and band 4.1
- Abnormal sodium pump
- Deficiency of pyruvate kinase
- Abnormal Ankyrin or band 3.1
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