7.7.3 Zinc sulfate eye drops Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are supposed to analyse the API in these tablets following standard quality assurance guidelines. Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30]. Research the type of titration described. Describe the chemical structure of any reagents involved in the analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11). Formulate the relevant chemical equations. (a) (b) (c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9. This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30]. For each titration, the following volume of edetate solution has been used:

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question

how can i do this?

7.7.3 Zinc sulfate eye drops
Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use
is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to
analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are
supposed to analyse the API in these tablets following standard quality assurance guidelines.
Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of
the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30].
(a) Research the type of titration described. Describe the chemical structure of any reagents involved in the
analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11).
(b) Formulate the relevant chemical equations.
(c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the
titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9.
This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30].
For each titration, the following volume of edetate solution has been used:
Transcribed Image Text:7.7.3 Zinc sulfate eye drops Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are supposed to analyse the API in these tablets following standard quality assurance guidelines. Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30]. (a) Research the type of titration described. Describe the chemical structure of any reagents involved in the analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11). (b) Formulate the relevant chemical equations. (c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9. This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30]. For each titration, the following volume of edetate solution has been used:
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps with 3 images

Blurred answer
Knowledge Booster
Iodine Titrations
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY