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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter7: Safe Medication Administration

Section: Chapter Questions

Problem 3SST

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54. The volume of distribution of a drug is 350 L. Which of the following is most likely to account for this volume of distribution?
OA) Extensive binding to tissue proteins
B) Extensive hepatic metabolism
C) Inability to cross the blood-brain barrier
D) Low lipid solubility
E) Rapid renal excretion

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49. The bioavailability of drug X after oral administration is 38%. Which of the following best explains this level of systemic bioavailability? A) Adipose distribution B) Hepatic metabolism C) Plasma protein binding D) Pulmonary metabolism E) Renal metabolism
Please answer the following questions 1) Vd of a drug will be high when it is distributed in the following tissues except-a) Adipose tissueb) Brain and spinal cordc) Skeletal muscle tissued) Visceral fate) Mesentery tissuef) fats covering kidney and spleen 2) In a 2-comp. open model system the rate of drug disposition between compartents follow-a) zero orderb) 1-orderc) 2-rderd) 3-ordere) mixed orderf) none of the above 3) The likely molecular wt. of a drug for oral absorption is-a) no more than 400b) no more than 350c) no more than 550d) no more than 700e) no more than 650f) no more than 500
27. In a life-threatening situation when a therapeutic concentration of a drug is needed immediately, which of the following is the best means for choosing the loading dose? A) Bolus of five times the maintenance dose B) Infusion at five times the normal maintenance rate for 1 half-life C) Maintenance dose times body weight D) Maintenance doses with the dose interval equal to the half-life E) Steady-state plasma concentration times the volume of distribution
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Which of the following is a contraindication to anticoagulant use? A) Recent injury B) Diabetes C) Asthma D) Dizziness Which of the following is an antiplatelet medication? A) Diltiazem B) Labetalol C) Procainamide D) Aspirin A commonly shared action of all antiarrhythmics is that they _____________________. A) Inhibit calcium absorption B) Cause vasoconstriction C) Slow the heart rate D) Prevent bradycardia Which of the following medications is an ACE inhibitor? A) Aspirin B) Labetalol C) Lisinopril D) Simvastatin A Class II antiarrhythmic blocks ____________ channels. A) Potassium B) Beta C) Sodium D) Calcium A potential complication with the administration of a diuretic is ______________________. A) Hypothermia B) Hypernatremia C) Hypokalemia D) Hypoglycemia
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Which of the following medications is a beta blocker? A) Hydrochlorothiazide B) Lasix C) Atenolol D) Simvastatin Which of the following is a contraindication to the antiarrhythmic Amiodarone? A) Tachycardia B) Allergy to Lidocaine C) Bradycardia D) Hypertension Which of the following is a common side effect of cholesterol medication? A) Muscle pain B) Diabetes C) Headache D) Decreased urination Which of the following most accurately describes the mechanism of action of a "statin"? A) Inhibits platelet aggregation B) Inhibits sodium excretion in the kidneys C) Inhibits cholesterol production in the liver D) Inhibits sodium reabsorption in the loop of Henle Which of the following is an indication to the antiarrhythmic Amiodarone? A) Bradycardia B) Hypercalcemia C) Hypertension D) Supraventricular Tachycardia (SVT)
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