4. Thomas Morgan collected the following crossover gene frequencies while studying Drosophila. Bar-shaped eyes are indicated by the (B) allele, and carnation eyes are indicated by the allele (C). Fused veins on wings (F), leg length (A), and scalloped wings (D) are located on the same chromosomes. Construct a chromosome map. Which two genes are most likely going to be inherited together? Genes Crossover Frequency A & B 24.0% A & C 8.0% C & D A & F F & B 2.0% 16.0% 8.0% D& F 6,0%
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- 1. The allele G for yellow stigma is completely dominant to green (g). Supposingtwo strains of autotetraploid plants are available and their genotypes are as follows:GGgg – in this plant the gene is close to the centromereGggg – in this plant the gene is far from the centromere If these two plants are crossed:a) provide the gametes that can be obtained from the two plants;b) provide the genotypic and phenotypic ratios of the offspring. 2. Consider the illustration below. Diagram the configuration you would observe at Anaphase I if crossing-over happens within the inversion. (IMAGE ATTACHED)In Drosophila flies, the allele b gives a black body, and the allele b+ gives brown, the wild-typephenotype. The allele wx of a separate gene gives waxy wings, and wx+ gives non-waxy. The allele cn ofa third gene gives cinnabar eyes, and cn+ gives red. A female heterozygous for these three genes istestcrossed, and 745 progenies are produced which are phenotypically classified as follows:5 b+ wx+ cn+4 b wx cn53 b+ wx cn 49 b wx+ cn+287 b+ wx+ cn279 b wx cn+ 33 b+ wx cn+35 b wx+ cn Make a linkage map of the three genes. Compute for interference and explain what the derived valuemeans. Show complete solutions to support your answers.4. In Drosophila, three autosomal, recessive mutations are ebony body (e), sepia eye color (s), and hairless bristles (h). A female fly heterozygous at all loci was testcrossed with an ebony, sepia, hairless male; the progeny are shown below. Using the gene symbols stated åbove, answer the following questions. Phenotype Observed # of offspring Ebony sepia, hairless ebony, sepia 57 53 344 346 ral Hairless ebony, hairless Sepia wild type ebony, sepia, hairless Total offspring 11 9. 89 91 1000 A. Give the genotypes of the flies in the testcross. Write the answer using the gene symbols stated above and using proper notation. B. Deduce the linkage map showing all distances among the three genes. C. Calculate the interference. Show all work.
- 0. In Drosophila, the gene for cinnabar eye color is onchromosome 2, and the gene for scarlet eye color is onchromosome 3. A fly homozygous for both recessivecinnabar and scarlet alleles (cn/cn; st/st) is white-eyed.a. If male flies (containing chromosomes with thenormal gene order) heterozygous for cn and st allelesare crossed to white-eyed females homozygous forthe cn and st alleles, what are the expected phenotypes and their frequencies in the progeny?b. One unusual male heterozygous for cn and st alleles,when crossed to a white-eyed female, produced onlywild-type and white-eyed progeny. Explain the likelychromosomal constitution of this male.c. When the wild-type F1 females from the cross withthe unusual male were backcrossed to normal cn/cn;st/st males, the following results were obtained:wild type 45%cinnabar 5%scarlet 5%white 45%Diagram a genetic event at metaphase I that couldproduce the rare cinnabar or scarlet flies among theprogeny of the wild-type F1 females.1. In Drosophila melanogaster (fruit fly) experiment, if we are going to cross male and female red-eyed fruit flies, we have the resulting offspring ratio of 50% red-eyed for female, 25 % for red-eyed male and 25% for white-eyed male. Females which are either homozygous or heterozygous for a trait still expressed eye redness whereas males can easily be affected. Why is this so? a. Females are the carriers of a gene for eye redness b. Y chromosome is responsible for red eyes in fruit flies, c. The gene for eye redness is an X-link dominant trait, d. Having a red-eyed trait is dominantly expressed by females4. In Drosophila melanogaster, a yellow-bodied (dark coloured) male with vestigial (underformed) wings is crossed to a wildtype female (brown body, red eyes). The F1 generation are all wildtypes. An F1 male and female are crossed and the F2 progeny consists of 16 vestigial-winged males with yellow bodies, 48 yellow males with normal wings, 15 males with vestigial wings and yellow bodies, 49 wildtype males, 31 vestigial winged females with brown bodies and 97 wildtype females. Explain the inheritance pattern of the 2 genes.
- . The normal eye color of Drosophila is red, but strains inwhich all flies have brown eyes are available. Similarly,wings are normally long, but there are strains with shortwings. A female from a pure line with brown eyes andshort wings is crossed with a male from a normal pureline. The F1 consists of normal females and short-wingedmales. An F2 is then produced by intercrossing the F1.Both sexes of F2 flies show phenotypes as follows:38 red eyes, long wings38 red eyes, short wings18 brown eyes, long wings18 brown eyes, short wingsDeduce the inheritance of these phenotypes; useclearly defined genetic symbols of your own invention.State the genotypes of all three generations and thegenotypic proportions of the F1 and F2.Unpacking Problem 31Before attempting a solution to this problem, try answering thefollowing questions:1. What does the word normal mean in this problem?2. The words line and strain are used in this problem.What do they mean, and are they interchangeable?3. Draw a simple…In Drosophila (fruit flies), jammed wings (J), daughterless (da), curly wings (Cy), star eyes (S), and a black body (b) are determined by genes located on the same chromosome. Gene Combination Recombination Frequency J and Cy 34.9 J and da 1.7 S and Cy 4.8 Cy and b 42.4 S and da 38 b and S 47.2 What is the map unit distance between b and da?Answer map unitsRecord your answer as a value rounded to one decimal place.In Drosophila melanogaster white (w) and miniature (m) wings are controlled by X-linked recessive genes with a recombination fruequency between them of approximately 38%. Show the sexes, phenotypes and proportions of offspring expected from the following mating:a. ++/wm female X wm maleb. +m/w+ female X w+ malec. w+/+m female X ++ maleIf we assume that white eyes and miniature wings are not x-linked but are linkedto the autosomal genes, what phenotypic frequencies would you expect from this cross: ++/wm female X ++/wm male?
- 5. In Drosophila flies, the allele b gives a black body, and the allele b* gives brown, the wild-type phenotype. The allele wx of a separate gene gives waxy wings, and wx" gives non-waxy. The allele cn of a third gene gives cinnabareyes, and cn* gives red. Afemale heterozygous for these three genes is testcrossed, and 700 progenies are produced which are phenotypically classified as follows: 3 b* wx* cn* 63 b wx*cn+ 25 b* wx cn* 2 b wx cn 252 b* wx* cn 33 b wx* cn 75 b* wx cn 247 b wx cn* Make a linkage map of the three genes. Compute for interference and explain what the derived value means. Show complete solutions to support your answers.7. In rabbits, a locus involved in the control of coat colour may be occupied by any of fouralleles: Full colour (C), Sepia (ck), Cream (cd), or Albino (ca). A geneticist counted the numberof Full colour (C), Sepia (ck), Cream (cd) and Albino coat offspring resulting after crossesbetween Sepia (ck) and Cream (cd) coloured coated parents. The results were as follows.• Full colour (C): 152• Sepia (ck): 53• Cream (cd): 39• Albino (ca): 6Mendelian inheritance of this trait predicts that the ratio of Full colour (C) to Sepia (ck) to Cream(cd) to Albino (ca) should be 9:3:3:1. Do the experimental results support this mode ofinheritance?2. a. A Drosophila male from a true-breeding stockwith scabrous eyes was mated with a female from atrue-breeding stock with javelin bristles. Both scabrous eyes and javelin bristles are autosomal recessive mutant traits. The F1 progeny all had normaleyes and bristles. F1 females from this cross weremated with males with both scabrous eyes andjavelin bristles. Write all the possible phenotypicclasses of the progeny that could be produced from the cross of the F1 females with the scabrous, javelin males, and indicate for each class whether it is arecombinant or parental type.b. The cross in part (a) yielded the following progeny:77 scabrous eyes and normal bristles; 76 wild type(normal eyes and bristles); 74 normal eyes andjavelin bristles; and 73 scabrous eyes and javelinbristles. Are the genes governing these traits likelyto be linked, or do they instead assort independently? Why?c. Suppose you mated the F1 females from the crossin part (a) to wild-type males. Why would thiscross fail…